Christodoulou G N, Gargoulas A, Papaloukas A, Marinopoulou A, Sideris E
Acta Psychiatr Scand. 1977 Sep;56(3):215-22. doi: 10.1111/j.1600-0447.1977.tb03564.x.
Twenty-five children with radiologically confirmed primary peptic ulcers were investigated. All patients suffered from duodenal ulcer and there was an unexpected female preponderance. The frequency of introverted personalities was greater in the patients than in the controls. Five patients suffered from psychiatric disorders, three had histories of suicidal attempts and three reported homosexual experiences. Six patients had nicknames. Eight patients had been operated on for appendicitis. The above parameters were negative in all control cases. The patients had lower mean IQ, worse adaptation to school, more anxious and overprotective parents, higher frequency of faddiness in food and lower frequency of nail-biting than the controls. The onset of symptoms was preceded by psychotraumatic events in eight cases. The findings suggest that the manifestation of the genetic background of duodenal ulcer is strongly influenced by environmental factors and factors associated with the personality of the patients.
对25名经放射学确诊为原发性消化性溃疡的儿童进行了调查。所有患者均患有十二指肠溃疡，且意外地以女性居多。患者中内向性格的发生率高于对照组。5名患者患有精神疾病，3名有自杀未遂史，3名报告有同性恋经历。6名患者有昵称。8名患者曾因阑尾炎接受手术。上述参数在所有对照病例中均为阴性。与对照组相比，患者的平均智商较低，对学校的适应能力较差，父母更焦虑且过度保护，挑食频率较高，咬指甲频率较低。8例患者症状出现前有精神创伤事件。研究结果表明，十二指肠溃疡遗传背景的表现受到环境因素以及与患者性格相关因素的强烈影响。
