Contracept Fertil Sex. 1996 Sep;24(9):694-9.
FIVNAT registry collected information on 31320 individual assisted reproductive technology (ART) cycles in 1995, 76.8% being conventional in vitro fertilization (IVF) cycles, and 22.2% microinsemination cycles, mainly ICSI. The per recovery and per transfer pregnancy rates remained fairly stable, in comparison with 1994 at respectively 19.0% and 23.8%. There was a slight decrease in the number of recovered oocytes (8.4 +/- 5.7 vs 8.6 +/- 5.7), but as the fertilization rate increased from 46.3% to 48.6%, the final number of embryos was at the same level. The number of transferred embryos was still decreasing (2.59 +/- 0.99 vs 2.65 +/- 1.06). The take-home-baby rate was nearby 15%. Infertilities involving a tubal factor still decreased to 53.5%, and those involving a male factor (with the use of husband's or donor's semen) represented almost 50%, but the use of donor's semen has decreased, probably because of the development of ICSI. The stimulation regimens using GnRH analogues represented 91.9%, 78.9% being with a long blockage period. They were associated with the highest per transfer pregnancy rate (25.0%). The percentage of transfers with more than 3 embryos decreased from 18.6% to 14.7% (p < 0.001), indicating that French IVF units are still progressing towards a policy the aim of which being to reduce multiple pregnancies. The pregnancy rate was at 29.4% for transfers involving 3 embryos. Analysis on the IVF outcome concerned all the pregnancies (16423) and newborn (16228) from procedures realised between 1986 and 1994. The ectopic rate decreased progressively. There was also a recent decrease in the multiple pregnancies, even before selective réduction. In 1994, the triplet rate reached 1.8% and 4%, respectively after and before reduction. Compared to natural pregnancies, IVF pregnancies were associated to higher prematurity rate (overall, 27%, singleton, 9.2%), hypotrophy and perinatal mortality rates. There was no evidence of any increase in the malformation rate.
法国国家辅助生殖技术登记处（FIVNAT registry）收集了1995年31320例个体辅助生殖技术（ART）周期的信息，其中76.8%为常规体外受精（IVF）周期，22.2%为显微授精周期，主要是卵胞浆内单精子注射（ICSI）。与1994年相比，每次取卵和每次移植的妊娠率保持相当稳定，分别为19.0%和23.8%。回收的卵母细胞数量略有下降（8.4±5.7对8.6±5.7），但随着受精率从46.3%提高到48.6%，最终胚胎数量处于同一水平。移植胚胎的数量仍在下降（2.59±0.99对2.65±1.06）。活产婴儿率接近15%。涉及输卵管因素的不孕症仍降至53.5%，涉及男性因素（使用丈夫或供体精液）的不孕症占近50%，但供体精液的使用有所减少，可能是由于ICSI的发展。使用促性腺激素释放激素（GnRH）类似物的刺激方案占91.9%，其中78.9%为长方案。它们与最高的每次移植妊娠率（25.0%）相关。移植3个以上胚胎的比例从18.6%降至14.7%（p<0.001），这表明法国的IVF单位仍在朝着旨在减少多胎妊娠的政策迈进。移植3个胚胎的妊娠率为29.4%。对1986年至1994年期间进行的所有妊娠（16423例）和新生儿（16228例）的IVF结局进行了分析。异位妊娠率逐渐下降。即使在选择性减胎之前，多胎妊娠也有近期下降。1994年，减胎后和减胎前的三胎妊娠率分别达到1.8%和4%。与自然妊娠相比，IVF妊娠的早产率（总体为27%，单胎为9.2%）、低体重和围产期死亡率更高。没有证据表明畸形率有任何增加。
