[1995 FIVNAT evaluation].

FIVNAT registry collected information on 31320 individual assisted reproductive technology (ART) cycles in 1995, 76.8% being conventional in vitro fertilization (IVF) cycles, and 22.2% microinsemination cycles, mainly ICSI. The per recovery and per transfer pregnancy rates remained fairly stable, in comparison with 1994 at respectively 19.0% and 23.8%. There was a slight decrease in the number of recovered oocytes (8.4 +/- 5.7 vs 8.6 +/- 5.7), but as the fertilization rate increased from 46.3% to 48.6%, the final number of embryos was at the same level. The number of transferred embryos was still decreasing (2.59 +/- 0.99 vs 2.65 +/- 1.06). The take-home-baby rate was nearby 15%. Infertilities involving a tubal factor still decreased to 53.5%, and those involving a male factor (with the use of husband's or donor's semen) represented almost 50%, but the use of donor's semen has decreased, probably because of the development of ICSI. The stimulation regimens using GnRH analogues represented 91.9%, 78.9% being with a long blockage period. They were associated with the highest per transfer pregnancy rate (25.0%). The percentage of transfers with more than 3 embryos decreased from 18.6% to 14.7% (p < 0.001), indicating that French IVF units are still progressing towards a policy the aim of which being to reduce multiple pregnancies. The pregnancy rate was at 29.4% for transfers involving 3 embryos. Analysis on the IVF outcome concerned all the pregnancies (16423) and newborn (16228) from procedures realised between 1986 and 1994. The ectopic rate decreased progressively. There was also a recent decrease in the multiple pregnancies, even before selective réduction. In 1994, the triplet rate reached 1.8% and 4%, respectively after and before reduction. Compared to natural pregnancies, IVF pregnancies were associated to higher prematurity rate (overall, 27%, singleton, 9.2%), hypotrophy and perinatal mortality rates. There was no evidence of any increase in the malformation rate.