Scheurlen M
Medizinische Poliklinik, Universität, Würzburg.
Fortschr Med. 1996 Sep 20;114(26):319-21.
The hypothesis that colonization of the intestinal tract by yeasts (e.g. Candida albicans) can lead to disease in immunocompromised individuals is currently being discussed controversially. Proponents assume that toxins produced by the fungi can trigger such complaints as irritable bowel syndrome of the chronic fatigue syndrome, and that such chronic or recurrent infections may be caused by an intestinal reservoir of yeasts. Opponents of the hypothesis, however, point out that no hard data on the pathogenetic significance of an intestinal reservoir of yeasts are available, controlled studies have failed to demonstrate the effectiveness of antifungal treatment. Discussions are however, hampered by a lack of objective data. The postulated pathomechanisms therefore need to be clarified, diagnostic criteria developed, and the efficacy of the proposed therapeutic measures shown by controlled studies. Until this has been done, assumption about the pathogenicity of yeasts in the bowel, cannot be taken as a basis for binding therapeutic recommendations.
酵母（如白色念珠菌）在肠道内定植会导致免疫功能低下个体发病的假说，目前正受到争议性的讨论。支持者认为，真菌产生的毒素可引发诸如肠易激综合征或慢性疲劳综合征等症状，且此类慢性或复发性感染可能由肠道内酵母储存库引起。然而，该假说的反对者指出，目前尚无关于肠道酵母储存库致病意义的确切数据，对照研究也未能证明抗真菌治疗的有效性。不过，由于缺乏客观数据，讨论受到了阻碍。因此，需要阐明假定的发病机制，制定诊断标准，并通过对照研究证明所提议治疗措施的疗效。在此之前，关于酵母在肠道内致病性的假设不能作为具有约束力的治疗建议的依据。
