Müller J
MMW Munch Med Wochenschr. 1976 May 21;118(21):669-72.
The increasing use of antibacterial chemotherapy in the last four decades encourages the commensal colonization of man by candida yeasts. The sites of particular commensal colonization are the oropharyngeal cavity and the intestinal tract. They are the principal reservoirs from which candida infections can settle into other regions and organs. The metastasis of candida yeasts from the commensal reservoir into regions which are free of microorganisms in healthy persons, usually needs a stimulant noxa: an eliciting bacterial infection, a consumptive primary disease, immunosuppressive therapy among other factors. In the event of candida infection being superimposed on a bacterial infection, successful antibacterial chemotherapy may lead to a remission of the mycosis by removal of the primary noxa.
在过去四十年中,抗菌化疗的使用日益增加,这促使念珠菌酵母在人体形成共生定植。特定的共生定植部位是口腔和肠道。它们是主要的储存库,念珠菌感染可从这些部位扩散到其他区域和器官。念珠菌酵母从共生储存库转移到健康人无微生物的区域,通常需要一种刺激性损伤因素:引发细菌感染、消耗性原发性疾病、免疫抑制治疗等因素。如果念珠菌感染叠加在细菌感染之上,成功的抗菌化疗可能通过消除原发性损伤因素而导致霉菌病缓解。