[胃溃疡不同临床类型中胃黏膜前列腺素E浓度及白细胞介素-1（IL-1）的合成]
[Prostaglandins E concentration in gastric mucosa and synthesis of interleukin-1 (IL-1) in different clinical variants of gastric ulcer].
作者信息
Mikriukova V I, Beloborodova E I
机构信息
Department of Therapy, Siberian Medical Institute, Tomsk.
出版信息
Klin Med (Mosk). 1996;74(4):38-9.
PMID:8999150
Abstract
Measurements of serum IL-1 levels and PGE-2 content in biopsies from gastric mucosa at ulcer margins were made in 30 patients with gastric ulcer running differently. The highest IL-1 production and low PGE-2 levels were typical for healing ulcer. Cicatrization was accompanied with normalization of IL-1 and PGE-2 values. Gastric ulcer with a severe course exhibited inhibited IL-1 synthesis and decreased production of PGE-2.
摘要
对30例病情各异的胃溃疡患者，测量了溃疡边缘胃黏膜活检组织中的血清白细胞介素-1（IL-1）水平和前列腺素E2（PGE-2）含量。愈合期溃疡的典型特征是IL-1产生量最高且PGE-2水平较低。瘢痕形成伴随着IL-1和PGE-2值的正常化。病情严重的胃溃疡表现为IL-1合成受抑制和PGE-2产生减少。
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