[生理和药理剂量碘对甲状腺131碘摄取的影响——模型计算]
[Influence of physiological and pharmacological amounts of iodine on the 131I uptake of the thyroid gland--a model calculation].
作者信息
Wellner U, Alef K, Schicha H
机构信息
Klinik und Poliklinik für Nuklearmedizin, Universität zu Köln, Deutschland.
出版信息
Nuklearmedizin. 1996 Dec;35(6):251-63.
AIM
The aim of this paper was to use a iodine metabolism model in order to analyze theoretically the different aspects of the iodine metabolism.
METHOD
To perform this a three compartment model was developed.
RESULTS
With this model we examined the influence of physiological and pharmacological iodine amounts on the iodine-131 uptake in the thyroid gland and additionally the excretion of Iodine-131 after radiotherapy. It can be said, that an in-patient admission for a duration of at least three days to perform a radiotherapy is sensible (wise) and a iodine-poor diet prior to the radiotherapy is of advantage. Regarding the iodine blockade of the thyroid gland after a reactor accident the effects (outcome) of the German recommendations were compared with the WHO-guidelines.
CONCLUSION
The model of iodine metabolism is suited for analyses even if because of ethic or other limitations measurements at human beings are not possible.
目的
本文旨在运用碘代谢模型从理论上分析碘代谢的不同方面。
方法
为此建立了一个三室模型。
结果
利用该模型，我们研究了生理和药理剂量的碘对甲状腺摄取碘-131的影响，以及放疗后碘-131的排泄情况。可以说，住院至少三天以进行放疗是明智的，放疗前采用低碘饮食是有益的。关于反应堆事故后甲状腺的碘阻断，将德国建议的效果与世界卫生组织的指导方针进行了比较。
结论
碘代谢模型适用于分析，即使由于伦理或其他限制无法对人类进行测量。
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