Małyszko J S, Małyszko J, Pawlak K, Myśliwiec M
Z Kliniki Nefrologii AM w Białymstoku, Kierownik Kliniki.
Przegl Lek. 1996;53(8):600-3.
Disturbances in serum lipids, hemostasis and platelet functions are frequent features in some kidney diseases and may contribute to the progression of atherosclerosis with its complications. Recently, an attention has been paid on beneficial effects of fish oil on serum lipids and hemostasis, and proteinuria. The purpose of this work was to assess platelet functions, some hemostatic parameters and serum lipids in patients with chronic glomerulonephritis treated with Trienyl. The study was performed on 7 patients with glomerulonephritis, before, 3 and 6 months following fish oil treatment. A small and nonsignificant rise in cholesterol, HDL and LDL was found, whereas triglycerides level fell significantly following 3 and 6 months of therapy Fibrinogen concentration was lowered significantly 6 months following fish oil administration. Platelet aggregation in platelet-rich plasma remained unaltered during therapy, whereas platelet responses to ADP and arachidonic acid in the whole blood were inhibited after 6 months of the therapy. Unsaturated omega 3 fatty acids in Trienyl alter lipid metabolism, platelet/vessel wall interactions and proteinuria and therefore might be beneficial in therapy of glomerulonephritis, particularly in combination treatment.
血清脂质、止血和血小板功能紊乱是某些肾脏疾病的常见特征，可能会导致动脉粥样硬化及其并发症的进展。最近，人们关注到鱼油对血清脂质、止血和蛋白尿的有益作用。这项工作的目的是评估用Trienyl治疗的慢性肾小球肾炎患者的血小板功能、一些止血参数和血清脂质。该研究对7例肾小球肾炎患者在鱼油治疗前、治疗后3个月和6个月进行。发现胆固醇、高密度脂蛋白（HDL）和低密度脂蛋白（LDL）有小幅且无显著意义的升高，而治疗3个月和6个月后甘油三酯水平显著下降。鱼油给药6个月后纤维蛋白原浓度显著降低。治疗期间富含血小板血浆中的血小板聚集未改变，而治疗6个月后全血中血小板对二磷酸腺苷（ADP）和花生四烯酸的反应受到抑制。Trienyl中的不饱和ω-3脂肪酸改变脂质代谢、血小板/血管壁相互作用和蛋白尿，因此可能对肾小球肾炎的治疗有益，特别是在联合治疗中。
