Mittrücker H W, Matsuyama T, Grossman A, Kündig T M, Potter J, Shahinian A, Wakeham A, Patterson B, Ohashi P S, Mak T W
Department of Immunology, University of Toronto, Toronto, Ontario, M5G 2C1, Canada.
Science. 1997 Jan 24;275(5299):540-3. doi: 10.1126/science.275.5299.540.
Lymphocyte-specific interferon regulatory factor (LSIRF) (now called IRF4) is a transcription factor expressed only in lymphocytes. Mice deficient in IRF4 showed normal distribution of B and T lymphocyes at 4 to 5 weeks of age but developed progressive generalized lymphadenopathy. IRF4-deficient mice exhibited a profound reduction in serum immunoglobulin concentrations and did not mount detectable antibody responses. T lymphocyte function was also impaired in vivo; these mice could not generate cytotoxic or antitumor responses. Thus, IRF4 is essential for the function and homeostasis of both mature B and mature T lymphocytes.
淋巴细胞特异性干扰素调节因子（LSIRF）（现称为IRF4）是一种仅在淋巴细胞中表达的转录因子。IRF4基因缺陷的小鼠在4至5周龄时B和T淋巴细胞分布正常，但出现进行性全身性淋巴结病。IRF4基因缺陷的小鼠血清免疫球蛋白浓度显著降低，且未产生可检测到的抗体反应。T淋巴细胞功能在体内也受损；这些小鼠无法产生细胞毒性或抗肿瘤反应。因此，IRF4对于成熟B淋巴细胞和成熟T淋巴细胞的功能及稳态至关重要。
