Nath H B, Griffiths R C
School of Applied Science, Monash University, Gippsland Campus, Churchill, Victoria, 3842, Australia.
Theor Popul Biol. 1996 Dec;50(3):227-53. doi: 10.1006/tpbi.1996.0030.
Estimation for an island model where mutation maintains a k-allele neutral polymorphism at a single locus on each island is considered. The likelihood of an observed sample type configuration is obtained by applying a computational algorithm analogous to Griffiths and Tavaré (Theor. Popul. Biol. 46 (1994), 131-159). This allows the computation of sampling distributions in an island model and investigation of their properties. Given a sample type configuration, the maximum likelihood estimate of the migration parameter is obtained by simulating independently the likelihood at a grid of points and, also, using a surface simulation method. The latter method generates the whole likelihood trajectory in a single application of the simulation program. An estimate of variance of the estimate of the migration parameter is obtained using the likelihood trajectory. A comparison of the maximum likelihood estimates of the gene flow between subpopulations is made with those obtained by using Wright's FST statistic.
我们考虑了一个岛屿模型的估计问题，其中突变在每个岛屿的单个位点上维持一个k等位基因的中性多态性。通过应用一种类似于格里菲思和塔瓦雷（《理论种群生物学》46（1994），131 - 159）的计算算法，得到了观察到的样本类型配置的似然性。这使得能够计算岛屿模型中的抽样分布并研究其性质。给定一个样本类型配置，通过在点网格上独立模拟似然性以及使用表面模拟方法，获得迁移参数的最大似然估计。后一种方法在模拟程序的单次应用中生成整个似然轨迹。使用似然轨迹获得迁移参数估计值的方差估计。将亚种群之间基因流的最大似然估计与使用赖特FST统计量获得的估计进行比较。
