Wirtschafter A, Schmidt R, Rosen D, Kundu N, Santoro M, Fusco A, Multhaupt H, Atkins J P, Rosen M R, Keane W M, Rothstein J L
Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University, Jefferson Medical College, Kimmel Cancer Center, Philadelphia, PA 19107, USA.
Laryngoscope. 1997 Jan;107(1):95-100. doi: 10.1097/00005537-199701000-00019.
Hashimoto's thyroiditis is an inflammatory disease of the thyroid gland with autoimmune etiology. Patients afflicted with Hashimoto's have a higher risk of thyroid malignancies such as papillary thyroid carcinoma. In the present study, we investigated the frequency of papillary thyroid carcinoma specific genes in patients diagnosed with Hashimoto's disease. The newly identified oncogenes RET/PTC1 and RET/PTC3 provide useful and specific markers of the early stages of papillary carcinoma as they are highly specific for malignant cells. Using a sensitive and specific reverse transcriptase-polymerase chain reaction (RT-PCR) assay, we found messenger RNA (mRNA) expression for the RET/PTC1 and RET/PTC3 oncogenes in 95% of the Hashimoto's patients studied. All Hashimoto's patients presenting without histopathologic evidence of papillary thyroid cancer showed molecular genetic evidence of cancer. These data suggest that multiple, independent occult tumors exist in these patients at high frequency.
桥本甲状腺炎是一种病因自身免疫的甲状腺炎症性疾病。患有桥本甲状腺炎的患者患甲状腺恶性肿瘤如乳头状甲状腺癌的风险更高。在本研究中，我们调查了被诊断为桥本氏病的患者中乳头状甲状腺癌特异性基因的频率。新发现的癌基因RET/PTC1和RET/PTC3是乳头状癌早期阶段有用且特异的标志物，因为它们对恶性细胞具有高度特异性。通过使用灵敏且特异的逆转录聚合酶链反应（RT-PCR）检测方法，我们在所研究的95%的桥本氏病患者中发现了RET/PTC1和RET/PTC3癌基因的信使核糖核酸（mRNA）表达。所有没有乳头状甲状腺癌组织病理学证据的桥本氏病患者都显示出癌症的分子遗传学证据。这些数据表明这些患者中高频存在多个独立的隐匿性肿瘤。
