Tsaur M L, Chou C C, Shih Y H, Wang H L
Institute of Neuroscience, National Yang-Ming University, Taipei, Taiwan, ROC.
FEBS Lett. 1997 Jan 3;400(2):215-20. doi: 10.1016/s0014-5793(96)01388-9.
A full-length K+ channel cDNA of Kv4.3, with an open reading frame of 611 amino acids, was isolated from rat hippocampus. Functional expression of Kv4.3 cDNA in Xenopus oocytes revealed an A-type K+ channel. In the central nervous system, Kv4.3 is most prominently expressed in the retrosplenial cortex, medial habenula, anterior thalamus, hippocampus, cerebellum, as well as lateral geniculate and superior colliculus, which are important for vision. The abundant expression of Kv4.3 in many CNS neurons supports its important role as a major component of subthreshold A currents in the control of action potentials and thus neuronal excitability.
从大鼠海马体中分离出了Kv4.3的全长钾离子通道cDNA，其开放阅读框为611个氨基酸。Kv4.3 cDNA在非洲爪蟾卵母细胞中的功能表达显示出一种A型钾离子通道。在中枢神经系统中，Kv4.3在压后皮质、内侧缰核、前丘脑、海马体、小脑以及外侧膝状体和上丘中表达最为显著，这些区域对视觉很重要。Kv4.3在许多中枢神经系统神经元中的大量表达支持了它作为阈下A电流的主要成分在控制动作电位从而控制神经元兴奋性方面的重要作用。
