Sprang M L, Isaacs J H, Boraca C T
Am J Obstet Gynecol. 1977 Sep 1;129(1):47-50. doi: 10.1016/0002-9378(77)90818-3.
Sixty-eight patients with in situ and seven patients with microinvasive cervical carcinoma were reviewed. Thirty per cent of the patients with carcinoma in situ were 30 years old and under. The mean age for carcinoma in situ was 37.8 years; for microinvasion, 42.6 years; and for postconization residual carcinoma, 48.5 years. Forty per cent of the patients were para 0 or 1. There was a 13 per cent incidence of postconization complications. The incidence of residual carcinoma in 58 patients who underwent conization and subsequent hysterectomy was only 10.3 per cent. The residual carcinoma was present high in the endocervical canal of the hysterectomy specimen. None of the patients with microinvasion had residual carcinoma. A positive correlation was found between the anatomic extent of the lesion on the conization specimen and the incidence of residual carcinoma. We conclude that conization and careful follow-up frequently are effective therapy for treating cervical carcinoma in situ, thereby reducing the incidence of hysterectomy.
对68例原位宫颈癌患者和7例微浸润宫颈癌患者进行了回顾性研究。30%的原位癌患者年龄在30岁及以下。原位癌患者的平均年龄为37.8岁；微浸润癌患者为42.6岁；锥切术后残留癌患者为48.5岁。40%的患者产次为0或1次。锥切术后并发症的发生率为13%。在58例行锥切术并随后行子宫切除术的患者中，残留癌的发生率仅为10.3%。残留癌存在于子宫切除标本的宫颈管上段。微浸润癌患者均无残留癌。在锥切标本上病变的解剖范围与残留癌的发生率之间发现了正相关。我们得出结论，锥切术和仔细的随访常常是治疗原位宫颈癌的有效方法，从而降低了子宫切除术的发生率。
