Fernandez-Borrachero O, Rubio J M, Delgado M J, Murillo M L, Carreras Sánchez O
Departamento de Fisiología y Biología Animal, Facultad de Farmacia, Universidad de Sevilla, España.
Ann Nutr Metab. 1996;40(5):283-6. doi: 10.1159/000177969.
This study was designed to determine the intestinal in vivo absorption of folic acid and methyltetrahydrofolate (MTHF) by the caecum surface at different times after 20 weeks of 30% ethanol ingestion. The absorption results were compared to the data of control rats. Chow and fluid consumption and body weight were significantly lower in ethanol-fed rats. The absorption of folic acid and MTHF by the caecum surface (pmol/cm2) was generally decreased in ethanol-fed rats at all concentrations assayed with respect to control animals (except for absorption of 0.5 and 2.5 microM folic acid at 15-min intervals). The results obtained in the present work also suggest a different absorptive behaviour of folic acid and MTHF in the caecum under the influence of chronic alcohol ingestion.
本研究旨在确定在摄入30%乙醇20周后的不同时间，叶酸和甲基四氢叶酸（MTHF）在盲肠表面的体内肠道吸收情况。将吸收结果与对照大鼠的数据进行比较。乙醇喂养的大鼠的食物摄入量、液体消耗量和体重显著降低。与对照动物相比，在所有测定浓度下，乙醇喂养的大鼠盲肠表面对叶酸和MTHF的吸收（pmol/cm²）普遍降低（15分钟间隔时0.5和2.5微摩尔叶酸的吸收除外）。本研究获得的结果还表明，在慢性酒精摄入的影响下，盲肠对叶酸和MTHF的吸收行为有所不同。
