Abe T, Furuhashi N, Yamaya Y, Wada Y, Hoshiai A, Suzuki M
Am J Obstet Gynecol. 1977 Sep 1;129(1):65-7. doi: 10.1016/0002-9378(77)90822-5.
Correlation between the climacteric symptoms and serum levels of estradiol. progesterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) was studied in 191 premenopausal and postmenopausal women. Significant correlation was obtained between the climacteric symptoms represented by the menopausal index of Kupperman and associates and serum levels of estradiol as well as LH in a subgroup of the premenopausal women, ages 35 to 39 years. The symptoms were shown to be significantly related in serum levels of LH and inversely related to estradiol. These results confirmed that climacteric symptoms, at least in premenopausal women 35 to 39 years of age, could result from a low output of ovarian estrogen and a high production of pituitary gonadotropin.
对191名绝经前和绝经后女性的更年期症状与血清雌二醇、孕酮、促卵泡激素（FSH）和促黄体生成素（LH）水平之间的相关性进行了研究。在35至39岁的绝经前女性亚组中，由库珀曼及其同事的绝经指数所代表的更年期症状与血清雌二醇以及LH水平之间存在显著相关性。结果显示，这些症状与血清LH水平显著相关，与雌二醇呈负相关。这些结果证实，至少在35至39岁的绝经前女性中，更年期症状可能是由于卵巢雌激素分泌不足和垂体促性腺激素分泌过多所致。
