同源白化和有色大鼠视网膜下丘脑束的分析。

Analysis of the retinohypothalamic tract in congenic albino and pigmented rats.

作者信息

Miller A M, Chappell R, Obermeyer W H, Benca R M

机构信息

University of Wisconsin-Madison, Neuroscience Training Program 53706, USA.

出版信息

Brain Res. 1996 Nov 25;741(1-2):348-51. doi: 10.1016/s0006-8993(96)01050-5.

DOI:10.1016/s0006-8993(96)01050-5

PMID:9001741

Abstract

To determine whether differences in the retinohypothalamic tract (RHT) were related specifically to albinism, we analyzed the distribution and trajectory of this pathway in congenic F344-c/+ albino and pigmented rats using the inactive subunit of cholera toxin conjugated to horseradish peroxidase as an anterograde tracer. We found that the overall volume of the tract in the albino rats was greater than in the pigmented rats (P < 0.05). We also noted shape differences.

摘要

为了确定视网膜下丘脑束（RHT）的差异是否与白化病有特定关联，我们使用与辣根过氧化物酶结合的霍乱毒素无活性亚基作为顺行示踪剂，分析了同基因F344-c/+白化大鼠和有色大鼠中该通路的分布和轨迹。我们发现，白化大鼠中该束的总体积大于有色大鼠（P < 0.05）。我们还注意到了形状差异。