Di Lieto A, De Rosa G, Albano G, Gallo F, Pontillo M, Micalef R, Colucci A, Paladini A
Department of Gynaecology, Obstetrics and Physiopathology of Human Reproduction, University of Naples, Federico II.
Clin Exp Obstet Gynecol. 1996;23(4):220-8.
Clinical and pathological changes of the mammary gland have been studied in 64 women affected by symptomatic Benign Breast Disease (BBD) coexisting with endometriosis or uterine leiomyomata. These patients were rendered hypoestrogenic by subcutaneous administration of the LH-RH analogue Goserelin depot [D-ser (tBu)6 Aza-Gly10-GnRH (ICI118630)] performed every 28 days, for six months. They were evaluated clinically and ultrasonographically before and after treatment to find possible changes of BBD as well as of endometriosis or uterine leiomyomata. Mammary biopsies were performed before and after treatment in all the patients to study the changes of EGF-R expression. Results showed that clinical improvement is accompanied with a reduction of EGF-R expression.
对64例患有症状性良性乳腺疾病（BBD）并伴有子宫内膜异位症或子宫平滑肌瘤的女性患者的乳腺临床和病理变化进行了研究。通过每28天皮下注射促性腺激素释放激素（LH-RH）类似物戈舍瑞林长效注射剂[D-丝氨酸（叔丁基）6氮杂甘氨酸10-促性腺激素释放激素（ICI118630）]使这些患者雌激素水平降低，持续6个月。在治疗前后对她们进行临床和超声检查，以发现BBD以及子宫内膜异位症或子宫平滑肌瘤可能出现的变化。对所有患者在治疗前后进行乳腺活检，以研究表皮生长因子受体（EGF-R）表达的变化。结果显示，临床症状改善的同时EGF-R表达降低。
