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肾移植术后晚期输尿管梗阻。是对既往排斥反应的纤维化反应吗?

Late ureteral obstruction after kidney transplantation. Fibrotic answer to previous rejection?

作者信息

Maier U, Madersbacher S, Banyai-Falger S, Susani M, Grünberger T

机构信息

Department of Urology, University of Vienna, Austria.

出版信息

Transpl Int. 1997;10(1):65-8. doi: 10.1007/BF02044345.

DOI:10.1007/BF02044345
PMID:9002155
Abstract

Today, the incidence of urological complications following renal transplantation is 2%-10%. Most of these complications occur within the 1st year and affect the distal ureter. We report on two patients who developed very late ureteral obstruction, 14 and 18 years after transplantation. Both patients had rejection episodes 1 and 10 months prior to the ureteral stenosis. Histological examination of one resected ureter revealed findings strongly suggestive of a rejection process. Open surgery with antirefluxive reimplantation into the bladder was successful in both patients, with a postoperative observation time of 20 and 8 months, respectively. We conclude that a percutaneous nephrostomy may be required in patients with rising creatinine and incipient hydronephrosis even long after transplantation has been performed.

摘要

如今,肾移植后泌尿系统并发症的发生率为2% - 10%。这些并发症大多发生在第1年内,且累及输尿管远端。我们报告了2例患者,他们在移植后14年和18年出现了非常晚期的输尿管梗阻。两名患者在输尿管狭窄前1个月和10个月均有排斥反应发作。对其中一条切除的输尿管进行组织学检查,结果强烈提示为排斥反应过程。两名患者均成功接受了开放手术,将输尿管抗反流再植入膀胱,术后观察时间分别为20个月和8个月。我们得出结论,即使在移植多年后,对于肌酐升高和早期肾积水的患者,可能仍需要进行经皮肾造瘘术。

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1
Late ureteral obstruction after kidney transplantation. Fibrotic answer to previous rejection?肾移植术后晚期输尿管梗阻。是对既往排斥反应的纤维化反应吗?
Transpl Int. 1997;10(1):65-8. doi: 10.1007/BF02044345.
2
[Urological complications in patient after kidney transplantation. Correction of ureter stenosis with consequent proper renal graft function].[肾移植术后患者的泌尿系统并发症。输尿管狭窄的矫正及随之而来的肾移植功能正常化]
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The manifestation and management of late urological complications in renal transplant recipients: use of the urological armamentarium.肾移植受者晚期泌尿系统并发症的表现与处理:泌尿外科诊疗手段的应用
J Urol. 1985 Nov;134(5):944-8. doi: 10.1016/s0022-5347(17)47540-9.
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Late ureteral obstruction mimicking rejection after renal transplantation.肾移植术后酷似排斥反应的晚期输尿管梗阻
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Fibrosis of a renal transplant ureter.肾移植输尿管纤维化。
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Impact of ureteral stricture and treatment choice on long-term graft survival in kidney transplantation.输尿管狭窄及其治疗选择对肾移植后长期移植物存活的影响。
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引用本文的文献

1
Renal Transplant Hydroureteronephrosis as a Manifestation of Rejection: An Under-Recognized Entity?以肾移植后肾盂输尿管积水为表现的排斥反应:一种未被充分认识的情况?
Case Rep Nephrol Dial. 2021 Mar 15;11(1):87-94. doi: 10.1159/000514199. eCollection 2021 Jan-Apr.
2
Extensive ureteral stricture in renal transplant recipients: prevalence and impact on graft and patient survival.
Int J Organ Transplant Med. 2013;4(4):165-71.