Thrall D E
Department of Anatomy, Physiological Sciences and Radiology, College of Veterinary Medicine, North Carolina State University, Raleigh, USA.
Vet Clin North Am Small Anim Pract. 1997 Jan;27(1):21-35. doi: 10.1016/s0195-5616(97)50003-9.
The biologic effects of ionizing radiation are well understood. The limitations of radiation therapy time-dose schemes typically used in veterinary medicine are also well understood. Before expensive and potentially toxic combinations of treatment, such as radiation combined with chemotherapy or radiation combined with hyperthermia, can be fully understood, the effect of optimizing the manner in which radiation itself is administered must first be defined. This will only occur after a sufficient period of observation after improvement of the radiation time-dose schemes in use today. Also, when evaluating historic data regarding the response of canine and feline tumors to irradiation, the time-dose scheme used must be considered. Many papers were published based on coarsely fractionated schemes using large doses per fraction and relatively low total doses. Thus, the response rates published must be tempered by the fact that it may be possible to obtain better tumor control rates using smaller doses per fraction and a larger total dose.
电离辐射的生物学效应已得到充分理解。兽医学中通常使用的放射治疗时间 - 剂量方案的局限性也已被充分理解。在能够充分理解诸如放疗联合化疗或放疗联合热疗等昂贵且可能有毒的治疗组合之前，必须首先明确优化放射治疗给药方式的效果。这只有在对当今使用的放射时间 - 剂量方案进行改进后经过足够长的观察期才会实现。此外，在评估关于犬猫肿瘤对放疗反应的历史数据时，必须考虑所使用的时间 - 剂量方案。许多论文是基于粗分割方案发表的，这些方案每次分割使用大剂量且总剂量相对较低。因此，已发表的反应率必须考虑到这样一个事实，即使用较小的每次分割剂量和较大的总剂量可能会获得更好的肿瘤控制率。
