Gregianin M, Macrì C, Bui F, Varotto L, Zucchetta P
1st Nuclear Medicine Service, University and General Hospital of Padua, Italy.
Q J Nucl Med. 1995 Dec;39(4 Suppl 1):124-6.
Since December 1993, in the 1st Nuclear Medicine Service of the University of Padua, eleven somatostatin-receptor scintigraphic studies with 111In-labelled pentetreotide have been performed. The patients (6 men and 5 women, age 28-68, mean 45 years) were affected by a variety of tumors which supposedly express somatostatin receptors: 2 meningotheliomatous meningiomas post-surgery; 2 glucagonomas with liver metastases observed on CT; 2 patients with suspicion of insulinoma; 2 carcinoids, one after surgery; 1 ectopic-ACTH Cushing's syndrome; 1 intracranial germinoma, post-surgery, in whom the study was requested to evaluate a doubtful finding of pulmonary metastatic lesion on CT; and 1 acromegaly showing, on MRI, and empty sella turcica occupied by and extraflexion of the lower portion of the chiasmatic cisterna without signs of adenoma and the sphenoidal sinus occupied by tissue wit inflammmatory characteristics. Somatostatin-receptor whole body scintigraphy was performed 4 and 24 hours after intravenous injection of 110 MBq 111In-pentetreotide (Octreoscan 111); spot images were acquired when judged necessary. In one case of glucagonoma, a tomographic scan (SPECT) was also performed to better evaluate the spatial relationship between the primitive pancreatic tumor and surrounding tissues. Focal accumulation of 111In-pentetreotide was scintigraphically detected in 5 of the 11 cases. Intense uptake of the radiopharmaceutical was observed in the meningiomas, in the glucagonomas with liver metastases, and in the case of acromegaly, corresponding to a GH-secreting adenoma. The negative scans seem to be true negative scans with the possible exception of one patient with a still unconfirmed suspicion of insulinoma, still not confirmed.
自1993年12月起，在帕多瓦大学第一核医学科，已开展了11项使用111In标记的喷替肽进行的生长抑素受体闪烁扫描研究。患者（6名男性和5名女性，年龄28 - 68岁，平均45岁）患有多种推测表达生长抑素受体的肿瘤：2例术后脑膜瘤型脑膜瘤；2例经CT观察到有肝转移的胰高血糖素瘤；2例疑似胰岛素瘤患者；2例类癌，其中1例术后；1例异位促肾上腺皮质激素性库欣综合征；1例术后颅内生殖细胞瘤，该项研究旨在评估CT上可疑的肺转移病变；以及1例肢端肥大症患者，MRI显示蝶鞍空虚，交叉池下部有额外延伸，无腺瘤迹象，蝶窦被具有炎症特征的组织占据。在静脉注射110 MBq 111In - 喷替肽（奥曲肽扫描111）后4小时和24小时进行生长抑素受体全身闪烁扫描；必要时采集局部图像。在1例胰高血糖素瘤患者中，还进行了断层扫描（SPECT）以更好地评估原发性胰腺肿瘤与周围组织的空间关系。11例患者中有5例通过闪烁扫描检测到111In - 喷替肽的局灶性聚集。在脑膜瘤、有肝转移的胰高血糖素瘤以及肢端肥大症患者（对应分泌生长激素的腺瘤）中观察到放射性药物的强烈摄取。除1例仍未确诊的疑似胰岛素瘤患者外，阴性扫描似乎为真正的阴性扫描，该例患者仍未得到确诊。
