Kostrzewska A, Laudański T, Batra S
Institute of Obstetrics & Gynaecology, Medical Academy, Bialystok, Poland.
Acta Obstet Gynecol Scand. 1996 Nov;75(10):886-91. doi: 10.3109/00016349609055022.
The effects of cromakalim and pinacidil on the contractile activity of the isolated human myometrium and intramyometrial arteries were studied.
Myometrial strips and pieces of uterine arteries were obtained from women undergoing hysterectomy. Contractions were recorded under isometric conditions.
Both compounds (10(-9) M-5 x 10(-6) M) inhibited the spontaneous activity of the myometrium and vasopressin induced contractions of myometrium and intramyometrial arteries. There was no statistically significant difference in the responses of both tissues to cromakalim or pinacidil. Both compounds reduced responses of myometrium and intramyometrial arteries to low concentration of K+ (< 40 mM) but did not decrease contractions induced by 40 mM and 80 mM.
The combined effect on the uterus and intrauterine vasculature would suggest a potential in the use of cromakalim or pinacidil for the treatment of dysmenorrhea.
研究克罗卡林和吡那地尔对离体人子宫肌层及子宫肌层内动脉收缩活性的影响。
子宫肌层条和子宫动脉片段取自接受子宫切除术的女性。在等长条件下记录收缩情况。
两种化合物（10⁻⁹M - 5×10⁻⁶M）均抑制子宫肌层的自发活性以及血管加压素诱导的子宫肌层和子宫肌层内动脉的收缩。两种组织对克罗卡林或吡那地尔的反应无统计学显著差异。两种化合物均降低了子宫肌层和子宫肌层内动脉对低浓度钾离子（<40 mM）的反应，但未降低由40 mM和80 mM钾离子诱导的收缩。
对子宫和子宫内血管系统的联合作用表明，克罗卡林或吡那地尔在治疗痛经方面具有潜在应用价值。
