Fiçicioğlu C, Api M, Ozden S
Zeynep Kamil Maternity Hospital, Infertility Polyclinic Department, Istanbul, Turkey.
Acta Obstet Gynecol Scand. 1996 Nov;75(10):917-21. doi: 10.3109/00016349609055028.
To evaluate whether the number of follicles and ovarian volume have any significance in evaluating the response to clomiphene citrate treatment in polycystic ovarian syndrome (PCOS).
A prospective study of 70 infertile women, 44 of which were diagnosed with polycystic ovarian syndrome.
Follicle numbers and volumes in both ovaries, hormonal profile, response to Clomiphene Citrate(CC).
Ovarian volume was significantly greater in cases with polycystic ovarian syndrome than controls. However, ovarian volume in the Clomiphene Citrate nonresponders was significantly greater than in Clomiphene Citrate responders in the polycystic ovarian syndrome group. The number of small follicles was significantly higher in cases with polycystic ovarian syndrome than controls, and in the Clomiphene Citrate nonresponder group this number was also significantly higher than in Clomiphene Citrate responders. Endocrine features of patients with polycystic ovarian syndrome revealed that Dehydroepiandrostenedione sulfate, Androstenedione, follicle stimulating and luteinizing hormone do not discriminate between patients who respond to Clomiphene Citrate and those who do not respond. However, Testosterone and luteinizing hormone levels differ significantly in responders and nonresponders.
Small multiple follicles (> 9) and enlarged ovarian volume (> 6.8 ml) were the most prominent transvaginal ultrasonographic features of ovaries in Clomiphene Citrate nonresponsive patients with polycystic ovarian syndrome. Higher levels of Testosterone, luteinizing hormone and significantly higher number of small follicles were associated with lack of Clomiphene Citrate response. These ultrasonographic features and laboratory assays could be clinically useful for distinguishing better the Clomiphene Citrate nonresponders from responders.
评估卵泡数量和卵巢体积在评估多囊卵巢综合征（PCOS）患者对枸橼酸氯米芬治疗反应方面是否具有任何意义。
对70名不孕女性进行的前瞻性研究，其中44名被诊断为多囊卵巢综合征。
双侧卵巢的卵泡数量和体积、激素水平、对枸橼酸氯米芬（CC）的反应。
多囊卵巢综合征患者的卵巢体积明显大于对照组。然而，在多囊卵巢综合征组中，枸橼酸氯米芬无反应者的卵巢体积明显大于有反应者。多囊卵巢综合征患者的小卵泡数量明显高于对照组，且在枸橼酸氯米芬无反应组中，该数量也明显高于有反应者。多囊卵巢综合征患者的内分泌特征显示，硫酸脱氢表雄酮、雄烯二酮、卵泡刺激素和黄体生成素无法区分对枸橼酸氯米芬有反应和无反应的患者。然而，睾酮和黄体生成素水平在有反应者和无反应者之间存在显著差异。
小卵泡数量多（>9个）和卵巢体积增大（>6.8 ml）是多囊卵巢综合征患者对枸橼酸氯米芬无反应者最突出的经阴道超声特征。较高的睾酮水平、黄体生成素水平以及明显较多的小卵泡数量与对枸橼酸氯米芬无反应相关。这些超声特征和实验室检测在临床上有助于更好地区分枸橼酸氯米芬无反应者和有反应者。
