Desrosiers M, Baroody F M, Proud D, Lichtenstein L M, Kagey-Sobotka A, Naclerio R M
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Md., USA.
J Allergy Clin Immunol. 1997 Jan;99(1 Pt 1):77-86. doi: 10.1016/s0091-6749(97)70303-8.
Ten subjects with asymptomatic seasonal allergy, outside of their allergy season, underwent allergen provocation following 1 hour of exposure to air at either 20 degrees C and 30% relative humidity (RH) or air at 37 degrees C and 90% RH. The ipsilateral changes following antigen challenge were compared under the two conditions. Conditioning of the nose to 37 degrees C, 90% RH reduced total histamine release (7.9 +/- 1.8 ng vs 4.2 +/- 1.3 ng; p < or = 0.05), sneezes (6 +/- 2 vs 3 +/- 1; p < or = 0.05), pruritus (score of 17.4 +/- 6.0 vs score of 2.0 +/- 1.8 out of a total score of 100, p < or = 0.01), nasal airway resistance (1.4 +/- 0.8 kPa/L/sec vs 0.2 +/- 0.1 kPa/L/sec; p < or = 0.05), human serum albumin levels (389.6 +/- 53.4 micrograms vs 242.2 +/- 37.9 micrograms; p < or = 0.05), and congestion (score of 23.8 +/- 4.8 vs score of 10.6 +/- 5.4 out of a total score of 100, p < or = 0.01). It had no effect on the volume of secretions (p = 0.8), lactoferrin levels (p = 0.3), or rhinorrhea (p = 1.0). Thus air at 37 degrees C and 90% RH partially reduces the early response to antigen. Its effects are greatest on histamine release, the vascular response, and neural responses, with no effect on the glandular response. The mechanisms underlying these effects are unknown.
10名无症状季节性过敏受试者在非过敏季节，于20摄氏度、相对湿度30%（RH）的空气中暴露1小时后，或在37摄氏度、相对湿度90%的空气中暴露1小时后，接受过敏原激发试验。比较两种条件下抗原激发后的同侧变化。将鼻腔调节至37摄氏度、90%相对湿度可降低总组胺释放量（7.9±1.8纳克对4.2±1.3纳克；p≤0.05）、喷嚏次数（6±2次对3±1次；p≤0.05）、瘙痒程度（总分100分中，17.4±6.0分对2.0±1.8分；p≤0.01）、鼻气道阻力（1.4±0.8千帕/升/秒对0.2±0.1千帕/升/秒；p≤0.05）、人血清白蛋白水平（389.6±53.4微克对242.2±37.9微克；p≤0.05）以及充血程度（总分100分中，23.8±4.8分对10.6±5.4分；p≤0.01）。对分泌物量（p = 0.8）、乳铁蛋白水平（p = 0.3）或鼻溢（p = 1.0）无影响。因此，37摄氏度、90%相对湿度的空气可部分减轻对抗原的早期反应。其对组胺释放、血管反应和神经反应的影响最大，对腺体反应无影响。这些影响的潜在机制尚不清楚。
