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1
Anabaena flos-aquae and other cyanobacteria possess diadenosine 5',5"'-P1,P4-tetraphosphate (Ap4A) phosphorylase activity.水华鱼腥藻和其他蓝细菌具有二腺苷5′,5″-P1,P4-四磷酸（Ap4A）磷酸化酶活性。
Biochem J. 1996 Dec 15;320 ( Pt 3)(Pt 3):795-800. doi: 10.1042/bj3200795.
2
The cyanobacterium Anabaena flos-aquae possesses diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) phosphorylase activity.水华鱼腥藻这种蓝细菌具有二腺苷5′,5″′-P1,P4-四磷酸（Ap4A）磷酸化酶活性。
Biochem Soc Trans. 1996 Aug;24(3):417S. doi: 10.1042/bst024417s.
3
The green alga Scenedesmus obliquus contains both diadenosine 5',5'''-P1,P4-tetraphosphate (asymmetrical) pyrophosphohydrolase and phosphorylase activities.绿藻斜生栅藻同时含有二腺苷5′,5″′-P1,P4-四磷酸（不对称）焦磷酸水解酶和磷酸化酶活性。
Biochem J. 1994 May 15;300 ( Pt 1)(Pt 1):183-9. doi: 10.1042/bj3000183.
4
Phosphorolytic cleavage of diadenosine 5',5'''-P1,P4-tetraphosphate. Properties of homogeneous diadenosine 5',5'''-P1,P4-tetraphosphate alpha, beta-phosphorylase from Saccharomyces cerevisiae.5',5'''-P1,P4-四磷酸二腺苷的磷酸解裂解。来自酿酒酵母的均一5',5'''-P1,P4-四磷酸二腺苷α,β-磷酸化酶的性质。
J Biol Chem. 1985 Mar 25;260(6):3542-7.
5
Diadenosine 5',5'''-P1, P4-tetraphosphate alpha, beta-phosphorylase from yeast supports nucleoside diphosphate-phosphate exchange.来自酵母的二腺苷5′,5‴-P1,P4-四磷酸α,β-磷酸化酶可支持核苷二磷酸-磷酸交换。
J Biol Chem. 1986 May 5;261(13):5943-6.
6
Chromate, molybdate, tungstate and vanadate behave as substrates of yeast diadenosine 5',5'''-p1,p4-tetraphosphate alpha, beta-phosphorylase.铬酸盐、钼酸盐、钨酸盐和钒酸盐可作为酵母二腺苷5',5'''-p1,p4-四磷酸α,β-磷酸化酶的底物。
Biochimie. 1986 May;68(5):757-60. doi: 10.1016/s0300-9084(86)80170-5.
7
Purification and molecular characterization of a novel diadenosine 5',5'''-P(1),P(4)-tetraphosphate phosphorylase from Mycobacterium tuberculosis H37Rv.结核分枝杆菌H37Rv新型二腺苷5',5'''-P(1),P(4)-四磷酸磷酸化酶的纯化及分子特性分析
Protein Expr Purif. 2010 Jan;69(1):99-105. doi: 10.1016/j.pep.2009.09.010. Epub 2009 Sep 22.
8
Synthesis of dinucleoside polyphosphates catalyzed by firefly luciferase.萤火虫荧光素酶催化的二核苷多磷酸的合成。
Eur J Biochem. 1991 Dec 5;202(2):507-13. doi: 10.1111/j.1432-1033.1991.tb16402.x.
9
Yeast diadenosine 5',5'''-P1,P4-tetraphosphate alpha,beta-phosphorylase behaves as a dinucleoside tetraphosphate synthetase.酵母二腺苷5′,5″′-P1,P4-四磷酸α,β-磷酸化酶表现为二核苷四磷酸合成酶。
Biochemistry. 1987 Jul 28;26(15):4763-8. doi: 10.1021/bi00389a025.
10
Catabolism of bis(5'-nucleosidyl) tetraphosphates in Saccharomyces cerevisiae.酿酒酵母中双（5'-核苷基）四磷酸的分解代谢
J Bacteriol. 1990 Dec;172(12):6892-9. doi: 10.1128/jb.172.12.6892-6899.1990.

引用本文的文献

1
Re-evaluation of Diadenosine Tetraphosphate (ApA) From a Stress Metabolite to Secondary Messenger.对四磷酸二腺苷（ApA）从应激代谢物到第二信使的重新评估。
Front Mol Biosci. 2020 Nov 17;7:606807. doi: 10.3389/fmolb.2020.606807. eCollection 2020.
2
Functional Characterization of COG1713 (YqeK) as a Novel Diadenosine Tetraphosphate Hydrolase Family.功能表征 COG1713（YqeK）作为一种新型二腺苷四磷酸水解酶家族。
J Bacteriol. 2020 Apr 27;202(10). doi: 10.1128/JB.00053-20.

本文引用的文献

1
Molecular cloning of diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase (Ap4A hydrolase) from porcine small intestine: relationship to other enzymes of Ap4A catabolism.猪小肠中二腺苷 5',5'''-P1,P4-四磷酸焦磷酸水解酶（Ap4A 水解酶）的分子克隆：与 Ap4A 分解代谢其他酶的关系
Biochem Soc Trans. 1996 Aug;24(3):418S. doi: 10.1042/bst024418s.
2
The cyanobacterium Anabaena flos-aquae possesses diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) phosphorylase activity.水华鱼腥藻这种蓝细菌具有二腺苷5′,5″′-P1,P4-四磷酸（Ap4A）磷酸化酶活性。
Biochem Soc Trans. 1996 Aug;24(3):417S. doi: 10.1042/bst024417s.
3
The FHIT gene 3p14.2 is abnormal in lung cancer.FHIT基因3p14.2在肺癌中存在异常。
Cell. 1996 Apr 5;85(1):17-26. doi: 10.1016/s0092-8674(00)81078-8.
4
The diadenosine polyphosphates Ap3A and Ap4A and adenosine triphosphate interact with granulocyte-macrophage colony-stimulating factor to delay neutrophil apoptosis: implications for neutrophil: platelet interactions during inflammation.
Blood. 1996 Apr 15;87(8):3442-9.
5
The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers.FHIT基因跨越染色体3p14.2易碎位点和肾癌相关的t(3;8)断点，在消化道癌症中存在异常。
Cell. 1996 Feb 23;84(4):587-97. doi: 10.1016/s0092-8674(00)81034-x.
6
Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome.单细胞蓝藻聚球藻属6803菌株（Synechocystis sp. strain PCC6803）基因组的序列分析。I. 基因组图谱位置64%至92%的1兆碱基区域的序列特征。
DNA Res. 1995 Aug 31;2(4):153-66, 191-8. doi: 10.1093/dnares/2.4.153.
7
Cloning of the Schizosaccharomyces pombe gene encoding diadenosine 5',5"'-P1,P4-tetraphosphate (Ap4A) asymmetrical hydrolase: sequence similarity with the histidine triad (HIT) protein family.粟酒裂殖酵母中编码5',5'''-P1,P4-四磷酸二腺苷（Ap4A）不对称水解酶的基因克隆：与组氨酸三联体（HIT）蛋白家族的序列相似性
Biochem J. 1995 Dec 15;312 ( Pt 3)(Pt 3):925-32. doi: 10.1042/bj3120925.
8
The green alga Scenedesmus obliquus contains both diadenosine 5',5'''-P1,P4-tetraphosphate (asymmetrical) pyrophosphohydrolase and phosphorylase activities.绿藻斜生栅藻同时含有二腺苷5′,5″′-P1,P4-四磷酸（不对称）焦磷酸水解酶和磷酸化酶活性。
Biochem J. 1994 May 15;300 ( Pt 1)(Pt 1):183-9. doi: 10.1042/bj3000183.
9
Conservation analysis and structure prediction of the protein serine/threonine phosphatases. Sequence similarity with diadenosine tetraphosphatase from Escherichia coli suggests homology to the protein phosphatases.蛋白质丝氨酸/苏氨酸磷酸酶的保守性分析与结构预测。与来自大肠杆菌的二腺苷四磷酸酶的序列相似性表明其与蛋白质磷酸酶具有同源性。
Eur J Biochem. 1994 Feb 15;220(1):225-37. doi: 10.1111/j.1432-1033.1994.tb18618.x.
10
Inhibition of casein kinase II by dinucleoside polyphosphates.二核苷多磷酸对酪蛋白激酶II的抑制作用。
Enzyme Protein. 1993;47(1):14-21. doi: 10.1159/000468651.

水华鱼腥藻和其他蓝细菌具有二腺苷5′,5″-P1,P4-四磷酸（Ap4A）磷酸化酶活性。

Anabaena flos-aquae and other cyanobacteria possess diadenosine 5',5"'-P1,P4-tetraphosphate (Ap4A) phosphorylase activity.

作者信息

McLennan A G, Mayers E, Adams D G

机构信息

School of Biological Sciences, University of Liverpool, U.K.

出版信息

Biochem J. 1996 Dec 15;320 ( Pt 3)(Pt 3):795-800. doi: 10.1042/bj3200795.

DOI:10.1042/bj3200795
PMID:9003364
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1217999/
Abstract

Diadenosine 5',5"'-P1,P4-tetraphosphate (Ap4A) phosphorylase, previously only known in lower eukaryotes, has been detected in extracts of the cyanobacteria Anabaena flos-aquae, Anabaena variabilis and Synechococcus sp. The 32 kDa enzyme was partially purified from A. flos-aquae and separated from a 23 kDa hydrolytic activity. It had a pH optimum of 9.5 and required a bivalent cation for activity: Mg2+, Mn2+, Ca2+, Co2+ or Zn2+. Diadenosine tri-, tetra- and penta-phosphates were all effective substrates (relative rates 0.85, 1.00 and 0.27 respectively), while the hexaphosphate was a poor substrate and the diphosphate was inactive. ADP was always one of the products of phosphorolysis. Arsenate and vanadate could substitute for phosphate (relative rates 1.80, 2.25 and 1.00 respectively), but tungstate and sulphate could not. Chromate and molybdate were poor substrates. A search of the GenBank non-redundant database revealed a putative Ap4A phosphorylase gene in the cyanobacterium Synechocystis sp. The gene showed significant blocks of identity/similarity with yeast Ap4A phosphorylases I and II, particularly the latter.

摘要

5',5''-P1,P4-四磷酸二腺苷（Ap4A）磷酸化酶以前仅在低等真核生物中被发现，现已在水华鱼腥藻、多变鱼腥藻和聚球藻属蓝细菌的提取物中检测到。这种32 kDa的酶从水华鱼腥藻中得到了部分纯化，并与一种23 kDa的水解活性分离。它的最适pH为9.5，活性需要二价阳离子：Mg2+、Mn2+、Ca2+、Co2+或Zn2+。三磷酸二腺苷、四磷酸二腺苷和五磷酸二腺苷都是有效的底物（相对速率分别为0.85、1.00和0.27），而六磷酸二腺苷是较差的底物，二磷酸二腺苷无活性。ADP始终是磷酸解的产物之一。砷酸盐和钒酸盐可以替代磷酸盐（相对速率分别为1.80、2.25和1.00），但钨酸盐和硫酸盐则不能。铬酸盐和钼酸盐是较差的底物。在GenBank非冗余数据库中搜索发现，蓝细菌聚球藻属中有一个假定的Ap4A磷酸化酶基因。该基因与酵母Ap4A磷酸化酶I和II有显著的同源/相似区域，尤其是与后者。