动脉血氧分压降低大鼠肝细胞培养物中静脉周围葡萄糖激酶的胰岛素依赖性诱导：过氧化氢对动脉血氧分压的模拟。
Arterial oxygen partial pressures reduce the insulin-dependent induction of the perivenously located glucokinase in rat hepatocyte cultures: mimicry of arterial oxygen pressures by H2O2.
作者信息
Kietzmann T, Roth U, Freimann S, Jungermann K
机构信息
Institut für Biochemie und Molekulare Zellbiologie, Göttingen, Federal Republic of Germany.
出版信息
Biochem J. 1997 Jan 1;321 ( Pt 1)(Pt 1):17-20. doi: 10.1042/bj3210017.
Abstract
Liver glucokinase (GK) is localized predominantly in the perivenous zone. GK mRNA was induced by insulin maximally under venous O2 partial pressure (pO2) and only half-maximally under arterial pO2. CoCl2 and desferrioxamine mimicked venous pO2 and enhanced the insulin-dependent induction of GK mRNA under arterial pO2. H2O2 mimicked arterial pO2 and reduced insulin-induced GK mRNA under venous pO2 to the lower arterial levels. Thus the zonal O2 gradient in liver seems to have a key role in the heterogenous expression of the GK gene.
摘要
肝脏葡萄糖激酶（GK）主要定位于肝静脉周围区域。在静脉氧分压（pO2）条件下，胰岛素对GK mRNA的诱导作用最强，而在动脉pO2条件下，诱导作用仅为最大诱导量的一半。氯化钴和去铁胺模拟静脉pO2，并增强了动脉pO2条件下胰岛素对GK mRNA的依赖性诱导作用。过氧化氢模拟动脉pO2，并将静脉pO2条件下胰岛素诱导的GK mRNA降低至较低的动脉水平。因此，肝脏中的区域氧梯度似乎在GK基因的异质性表达中起关键作用。
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