García H, Henriquez C, Ugarte F, Fernandez E, Beas F, Iñiguez G, Boric A, Pizarro F, Cassorla F
Instituto de Investigaciones Materno Infantil, Facultad de Medicina, Universidad de Chile, Hospital San Borja Arriarán, Santiago, Chile.
J Pediatr Endocrinol Metab. 1996 Nov-Dec;9(6):561-7. doi: 10.1515/jpem.1996.9.6.561.
The hormonal profile in 47 small for gestational age (SGA) term newborns during their first year of life was studied. The newborns had a mean birth weight of 2290 +/- 230 g and a length of 45.5 +/- 2.0 cm, and they were followed up every month. Serum IGF-I, IGF-II, and urinary growth hormone (u-GH) concentrations were measured at 3 days of age and every 3 months during one year. Serum IGFBP-3 levels were measured at 3 and 6 months of age. Catch up growth (CUG) was defined as an increase in length z score greater than 1 SD between birth and 6 months of age. According to this definition, 27 infants (57.4%) experienced CUG. We compared the hormonal profile of the infants who demonstrated evidence of CUG [CUG(+)] with those who did not [CUG(-)]. Serum IGF-II levels were significantly higher in CUG(+) infants compared to CUG(-) infants at 3 months of age. We did not find any differences in serum IGF-I, IGFBP-3 and urinary GH between CUG(+) and CUG(-) infants at any time during the study.
对47名小于胎龄（SGA）足月儿出生后第一年的激素水平进行了研究。这些新生儿的平均出生体重为2290±230克，身长为45.5±2.0厘米，每月进行随访。在出生3天时以及出生后一年内每3个月测量一次血清胰岛素样生长因子-I（IGF-I）、胰岛素样生长因子-II（IGF-II）和尿生长激素（u-GH）浓度。在出生3个月和6个月时测量血清胰岛素样生长因子结合蛋白-3（IGFBP-3）水平。追赶生长（CUG）定义为出生至6个月龄时身长z评分增加超过1个标准差。根据这一定义，27名婴儿（57.4%）出现了追赶生长。我们比较了有追赶生长证据的婴儿[CUG(+)]和没有追赶生长证据的婴儿[CUG(-)]的激素水平。在3个月龄时，CUG(+)婴儿的血清IGF-II水平显著高于CUG(-)婴儿。在研究期间的任何时候，我们都未发现CUG(+)和CUG(-)婴儿的血清IGF-I、IGFBP-3和尿生长激素水平存在差异。
