Orsi A J, Tax A W, Nuamah I, Barsevick A, McCorkle R
Department of Nursing, Temple University, Philadelphia, Pennsylvania, USA.
Cancer Pract. 1996 Sep-Oct;4(5):252-7.
The purposes of the investigation were: 1) to examine the natural killer (NK) cell levels in a homogeneous group of patients with cancer between the presurgical period and 6 months after surgery; 2) to identify changes in the number of NK cells over time; and 3) to determine whether an association exists among the number of NK cells, demographics, stage of cancer, and treatment variables.
A longitudinal descriptive design was used to study biopsychosocial factors in persons newly diagnosed with colorectal cancer over a 6-month period.
Patients without ostomies had a significant decrease in NK levels over time, whereas patients with ostomies had a significant increase in NK levels over time. There was a difference in NK level over time for patients who were receiving the additional therapy of radiation alone and a combination of radiation and chemotherapy from those patients who were not receiving additional therapy. Natural killer levels in patients who were receiving radiation alone or a combination of radiation and chemotherapy significantly declined over time, where NK levels in patients receiving no additional treatment significantly increased over time.
Patients with low NK levels should be monitored during the course of their illness and cancer treatment to determine the relationship to immune status of other variables such as nutritional status, infection rates, and functional status.
本研究的目的为：1）检查一组同质癌症患者术前及术后6个月的自然杀伤（NK）细胞水平；2）确定NK细胞数量随时间的变化；3）确定NK细胞数量、人口统计学特征、癌症分期和治疗变量之间是否存在关联。
采用纵向描述性设计，对新诊断为结直肠癌的患者在6个月期间的生物心理社会因素进行研究。
未行造口术的患者NK水平随时间显著下降，而行造口术的患者NK水平随时间显著上升。接受单纯放疗以及放疗与化疗联合治疗的患者与未接受额外治疗的患者相比，NK水平随时间存在差异。接受单纯放疗或放疗与化疗联合治疗的患者NK水平随时间显著下降，而未接受额外治疗的患者NK水平随时间显著上升。
NK水平较低的患者在疾病和癌症治疗过程中应进行监测，以确定其与其他变量（如营养状况、感染率和功能状态）免疫状态的关系。
