Hegerl U, Juckel G, Möller H J
Psychiatrische Klinik, Ludwig-Maximilians-Universität München.
Nervenarzt. 1996 May;67(5):360-8.
The increasing knowledge concerning anatomical structures and cellular processes underlying event-related potentials (ERP) and methodological advances in ERP data analysis are beginning to bridge the gap between ERP and neurochemical aspects. ERP reflect directly postsynaptic effects of cortical neurotransmitters (e.g. GABA, glutamate) and indirectly modulating effects of neuromodulators (e.g. serotonin, acetylcholine) on cortical neuronal functioning and are therefore promising as noninvasive indicators of the functioning of neurochemical systems. Several recent reports are summarised suggesting that quite specific relationships may exist between certain ERP parameters and central cholinergic, noradrenergic and especially serotonergic function. Converging arguments from preclinical and clinical studies are presented supporting the hypothesis that the dependence of the response of primary auditory cortices on stimulus intensity (loudness) is regulated by the level of central serotonergic neurotransmission. This intensity dependence is shown to be of clinical value because, within different diagnostic categories, subgroups of patients with a serotonergic dysfunction can be identified and can be treated more specifically with serotonergic drugs.
人们对事件相关电位（ERP）背后的解剖结构和细胞过程的了解日益增加，以及ERP数据分析方法的进步，正开始弥合ERP与神经化学方面之间的差距。ERP直接反映皮质神经递质（如γ-氨基丁酸、谷氨酸）的突触后效应，并间接反映神经调质（如血清素、乙酰胆碱）对皮质神经元功能的调节作用，因此有望成为神经化学系统功能的非侵入性指标。最近的几份报告总结表明，某些ERP参数与中枢胆碱能、去甲肾上腺素能，尤其是血清素能功能之间可能存在相当特定的关系。本文呈现了来自临床前和临床研究的一致观点，支持以下假设：初级听觉皮层对刺激强度（响度）的反应依赖性受中枢血清素能神经传递水平的调节。这种强度依赖性被证明具有临床价值，因为在不同的诊断类别中，可以识别出血清素能功能障碍患者的亚组，并可以用血清素能药物进行更具针对性的治疗。
