Cambien F
INSERM SC7, Paris, France.
Rev Epidemiol Sante Publique. 1996 Nov;44(6):530-9.
A global approach is required in the search for factors predisposing to multifactorial diseases. The analysis of genotypes must, of course, be integrated in addition to environmental factors and intermediary phenotypes as well as a precise evaluation of different clinical manifestations of the disease. A better understanding of the pathophysiological mechanisms involved is essential for intelligent selection of candidate genes, pertinent analysis of intermediary phenotypes and measurements of factors susceptible to influence the genetic effects. Strategy to identify factors of genetic susceptibility to frequent diseases does not necessarily involve linkage analysis.
在寻找多因素疾病的易患因素时需要采用全球通用的方法。当然，除了环境因素、中间表型以及对疾病不同临床表现的精确评估之外，还必须将基因型分析整合进去。更好地理解所涉及的病理生理机制对于明智地选择候选基因、对中间表型进行相关分析以及测量可能影响遗传效应的因素至关重要。识别常见疾病遗传易感性因素的策略不一定涉及连锁分析。
