[Genetic epidemiology and frequent multifactorial diseases].

A global approach is required in the search for factors predisposing to multifactorial diseases. The analysis of genotypes must, of course, be integrated in addition to environmental factors and intermediary phenotypes as well as a precise evaluation of different clinical manifestations of the disease. A better understanding of the pathophysiological mechanisms involved is essential for intelligent selection of candidate genes, pertinent analysis of intermediary phenotypes and measurements of factors susceptible to influence the genetic effects. Strategy to identify factors of genetic susceptibility to frequent diseases does not necessarily involve linkage analysis.