Yerly S, Rakik A, Kinloch-de-Loes S, Erb P, Vernazza P, Hirschel B, Perrin L
Laboratoire de virologie, Hôpital universitaire, Genève.
Schweiz Med Wochenschr. 1996 Oct 26;126(43):1845-8.
Zidovudine (ZDV) was the most widely used anti-HIV drug between 1987 and 1995, and, as already reported, transmission of ZDV-resistant viruses occurs. Several mutations of the reverse transcriptase gene have been identified; one of them affects the 215 codon and is associated with a high degree of resistance. We have determined, using selective PCR, the prevalence of transmission of 215 mutant isolates in 134 patients with primary HIV infection (PHI) and have identified 8 patients with 215 mutant virus between 1989 and 1995 in Switzerland. Mutant resistant viruses have been isolated from patients treated with most antiviral drugs. A systematic search for mutant viruses may provide useful information for the adaptation of treatment strategies.
齐多夫定（ZDV）在1987年至1995年间是使用最广泛的抗HIV药物，并且，如已报道的那样，会出现对ZDV耐药病毒的传播。已鉴定出逆转录酶基因的几种突变；其中一种影响215密码子并与高度耐药性相关。我们使用选择性PCR确定了134例原发性HIV感染（PHI）患者中215突变株的传播率，并于1989年至1995年在瑞士确定了8例携带215突变病毒的患者。已从接受大多数抗病毒药物治疗的患者中分离出耐药突变病毒。系统地搜索突变病毒可能为调整治疗策略提供有用信息。
