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[利用基因和表型标志物预测心肌梗死发生的概率]

[The prediction of the probability of the development of myocardial infarct by genetic and phenotypic markers].

作者信息

Gorbatovskiĭ Ia A, Filimonov S N, Lomosh E A, Luzina E A, Levchenko V G, Mikhaĭlovichev O Iu

出版信息

Ter Arkh. 1996;68(9):42-7.

PMID:9005612
Abstract

The study was made of marker distribution of 17 hereditary polymorphism systems in 493 patients with myocardial infarction (MI) and 422 healthy subjects. The prognostic system for determination of predisposition or resistance to MI development has been designed in accordance with marker occurrence in the patients and healthy subjects basing on Bayer's method. When the sum of the prognostic ratios of all the markers is +5 scores and more there is a high risk of MI, when this sum is -6 scores and less the resistance to its genesis is predicted. The proposed prognostic system makes it possible to predict predisposition to myocardial infarction at an early age and, therefore, to take preventive measures.

摘要

该研究对493例心肌梗死(MI)患者和422名健康受试者的17种遗传多态性系统的标志物分布进行了研究。根据患者和健康受试者中标志物的出现情况,基于拜耳方法设计了用于确定MI发生易感性或抗性的预后系统。当所有标志物的预后比率之和为+5分及以上时,发生MI的风险较高;当该总和为-6分及以下时,则预测对其发生具有抗性。所提出的预后系统能够在早期预测心肌梗死的易感性,从而采取预防措施。

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