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[切尔诺贝利原子能电站隔离区内实验室及野生啮齿动物骨髓细胞细胞遗传学变异性的异质性]

[The heterogeneity of the cytogenetic variability in the bone marrow cells of laboratory and wild rodents in the exclusion zone of the Chernobyl Atomic Electric Power Station].

作者信息

Glazko T T, Safonova N A, Buntova E G, Glazko G V, Sozinov A A

出版信息

Tsitol Genet. 1996 Jul-Aug;30(4):25-34.

PMID:9005633
Abstract

Analysis of the characters of cytogenetic variabilities and correlative interrelations between them revealed the group specificities of karyotype instability in bone marrow cells of some lines of laboratory and of wild mice under the conditions of increased radionuclide pollution in the Chernobyl zone. The complex correlative interrelations between the frequencies of cytogenetic anomalies and the character of cell division (the number of metaphases, binucleated leukocytes per 1000 cells) were observed. The obtained data indicate the stimulatory influence of chronic low doses of ionizing radiation on the manifestation of spontaneous mutagenesis, which has own genotype specific characteristics.

摘要

对细胞遗传学变异性特征及其相互关系的分析揭示了在切尔诺贝利地区放射性核素污染增加的情况下,一些实验室品系和野生小鼠骨髓细胞染色体核型不稳定性的群体特异性。观察到细胞遗传学异常频率与细胞分裂特征(中期相数量、每1000个细胞中的双核白细胞数量)之间存在复杂的相互关系。所得数据表明,慢性低剂量电离辐射对自发诱变的表现具有刺激作用,且自发诱变具有自身的基因型特异性特征。

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