[大鼠组织中烟酰胺和烟酸动态生物合成烟酰胺辅酶的研究]
[The dynamic biosynthesis of nicotinamide coenzymes from nicotinamide and nicotinic acid in rat tissues].
作者信息
Fedyk M Ia, Velykyĭ M M, Zababurina M L, Oliiarnyk O D
出版信息
Ukr Biokhim Zh (1978). 1996 Mar-Apr;68(2):29-33.
Dynamics of nicotinamide coenzyme biosynthesis in rat tissues has been studied systematically with previous injection of two main precursors nicotinic acid and nicotinamide (50 mg/100 g of weight. This process is characterized by exact tissue specificity. As a precursor of NAD-biosynthesis nicotinamide was used more intensively in the liver and brain tissues. In the mucous tissue of intestine nicotinic acid was utilized more intensively. An increase in the NADP+ content in tissues with high level of NAD+ biosynthesis is limited as a result of competition between these two processes for the intracellular ATP level.
通过预先注射两种主要前体烟酸和烟酰胺（50毫克/100克体重），系统研究了大鼠组织中烟酰胺辅酶生物合成的动力学。这个过程具有确切的组织特异性。作为NAD生物合成的前体，烟酰胺在肝脏和脑组织中被更广泛地利用。在肠道黏膜组织中，烟酸被更广泛地利用。由于这两个过程对细胞内ATP水平的竞争，NAD +生物合成水平高的组织中NADP +含量的增加受到限制。
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