Yu X M, Askalan R, Keil G J, Salter M W
Division of Neuroscience, Hospital for Sick Children, Department of Physiology, University of Toronto, Toronto, Ontario, M5G 1X8 Canada.
Science. 1997 Jan 31;275(5300):674-8. doi: 10.1126/science.275.5300.674.
The N-methyl-D-aspartate (NMDA) receptor mediates synaptic transmission and plasticity in the central nervous system (CNS) and is regulated by tyrosine phosphorylation. In membrane patches excised from mammalian central neurons, the endogenous tyrosine kinase Src was shown to regulate the activity of NMDA channels. The action of Src required a sequence [Src(40-58)] within the noncatalytic, unique domain of Src. In addition, Src coprecipitated with NMDA receptor proteins. Finally, endogenous Src regulated the function of NMDA receptors at synapses. Thus, NMDA receptor regulation by Src may be important in development, plasticity, and pathology in the CNS.
N-甲基-D-天冬氨酸（NMDA）受体介导中枢神经系统（CNS）中的突触传递和可塑性，并受酪氨酸磷酸化调节。在从哺乳动物中枢神经元切除的膜片中，内源性酪氨酸激酶Src被证明可调节NMDA通道的活性。Src的作用需要Src非催化独特结构域内的一个序列[Src(40-58)]。此外，Src与NMDA受体蛋白共沉淀。最后，内源性Src调节突触处NMDA受体的功能。因此，Src对NMDA受体的调节在CNS的发育、可塑性和病理学中可能很重要。
