Boecker H, Wills A J, Ceballos-Baumann A, Samuel M, Thomas D G, Marsden C D, Brooks D J
Medical Research Council (MRC) Cyclotron Unit, Hammersmith Hospitals, London, UK.
Ann Neurol. 1997 Jan;41(1):108-11. doi: 10.1002/ana.410410118.
Stereotactic thalamotomy is an effective treatment for severe drug-resistant tremor. The thalamus, however, facilitates motor activity, and thalamotomy would be predicted to inhibit movement-associated cortical activation. Two tremulous parkinsonian patients were studied with H2(15)O positron emission tomography before and after left ventralis intermedius thalamotomy. Subjects were scanned at rest and during performance of externally paced joystick movements in freely selected directions with the right hand. Thalamotomy relieved tremor but, as predicted, led to decreased activation of the left sensorimotor cortex, lateral premotor cortex, and parietal area 7 on hand movement.
立体定向丘脑切开术是治疗严重药物抵抗性震颤的有效方法。然而，丘脑促进运动活动，因此预计丘脑切开术会抑制与运动相关的皮层激活。对两名震颤型帕金森病患者在左侧腹中间核丘脑切开术前和术后进行了H2(15)O正电子发射断层扫描研究。受试者在休息时以及右手以自由选择的方向进行外部控制的操纵杆运动时接受扫描。丘脑切开术缓解了震颤，但正如预期的那样，导致手部运动时左侧感觉运动皮层、外侧运动前皮层和顶叶7区的激活减少。
