Johnson T E, Tabbara K F, Weatherhead R G, Kersten R C, Rice C, Nasr A M
King Khaled Eye Specialist Hospital, King Saud University, Riyadh, Saudi Arabia.
Arch Ophthalmol. 1997 Jan;115(1):75-8. doi: 10.1001/archopht.1997.01100150077013.
To evaluate the origin and biological behavior of secondary orbital squamous cell (SCC) and mucoepidermoid carcinoma.
A retrospective review of 30 consecutive patients with SCC and mucoepidermoid carcinoma of the orbit seen over a period of 8 years at a large ophthalmic hospital in Saudi Arabia.
A total of 51 secondary orbital tumors were seen in the 8-year period from 1983 through 1991; 30 (60%) of the 51 cases were SCC. There were 16 male and 14 female patients, with an age range of 38 to 80 years and a mean age of 65 years. In 28 (93%) of the 30 patients, the tumor originated in the conjunctiva. Orbital involvement by conjunctival SCC was the most common cause of secondary orbital tumors encountered in patients older than 19 years. Four patients had concomitant paranasal sinus involvement, 4 patients exhibited intraocular invasion, and 2 others were found to have intracranial extension of the SCC. Six (20%) of the 28 patients developed regional lymph node metastases during the course of their illness. All patients were treated by orbital exenteration, with or without radiation therapy. Seven (23%) of the 28 patients died of their disease.
Orbital SCC is an aggressive and life-threatening condition. Most cases result from secondary extension of conjunctival SCC, a common disease in Saudi Arabia. Several factors contribute to the aggressiveness of conjunctival SCC in this geographic location, including continual exposure to UV rays, chronic irritation, and genetic factors. Delay in presentation for treatment, inadequate initial resection of conjunctival lesions, and the aggressive mucoepidermoid carcinoma variant of SCC are also factors contributing to orbital invasion.
评估继发性眼眶鳞状细胞癌（SCC）和黏液表皮样癌的起源及生物学行为。
对沙特阿拉伯一家大型眼科医院8年间连续收治的30例眼眶SCC和黏液表皮样癌患者进行回顾性研究。
1983年至1991年的8年间共发现51例继发性眼眶肿瘤；51例中有30例（60%）为SCC。患者中男性16例，女性14例，年龄范围为38至80岁，平均年龄65岁。30例患者中有28例（93%）肿瘤起源于结膜。结膜SCC累及眼眶是19岁以上患者继发性眼眶肿瘤最常见的原因。4例患者伴有鼻窦受累，4例出现眼内侵犯，另外2例发现SCC有颅内扩展。28例患者中有6例（20%）在病程中出现区域淋巴结转移。所有患者均接受了眼眶内容剜除术，部分患者联合放疗。28例患者中有7例（23%）死于该病。
眼眶SCC是一种侵袭性且危及生命的疾病。大多数病例是由结膜SCC的继发性扩展引起的，结膜SCC在沙特阿拉伯是一种常见疾病。该地区结膜SCC的侵袭性由多种因素导致，包括持续暴露于紫外线、慢性刺激和遗传因素。治疗延迟、结膜病变初始切除不充分以及SCC的侵袭性黏液表皮样癌变体也是导致眼眶侵犯的因素。
