Francois I, Casteels I, Silberstein J, Casaer P, de Zegher F
Department of Paediatrics, U. Z. Gasthuisberg, Leuven, Belgium.
Eur J Pediatr. 1997 Jan;156(1):69-70. doi: 10.1007/s004310050556.
An 11-year-old boy with normal visus and eye fundus, but with empty sella, growth hormone (GH) deficiency and central diabetes insipidus was found to have intracranial hypertension with papilloedema after 6 months of catch-up growth under recombinant human GH (rhGH) replacement therapy. Withdrawal of rhGH therapy was associated with normalisation of intracranial pressure within 1 week. Three months later, resumption of rhGH therapy at a lower dose was again followed by pronounced growth acceleration, but now without papilloedema.
Children with empty sella and GH deficiency may be prone to rhGH-induced pseudotumour cerebri which appears to be rapidly reversible and dose-dependent.
一名11岁男孩，视力和眼底正常，但患有空蝶鞍、生长激素（GH）缺乏症和中枢性尿崩症，在重组人生长激素（rhGH）替代治疗下追赶生长6个月后，出现颅内高压伴视乳头水肿。停用rhGH治疗1周内颅内压恢复正常。3个月后，再次以较低剂量恢复rhGH治疗，随后又出现明显的生长加速，但此次没有视乳头水肿。
患有空蝶鞍和GH缺乏症的儿童可能易患rhGH诱导的假性脑瘤，这种情况似乎可迅速逆转且与剂量有关。
