Verdin E, Smitz S, Thibaut A, Born J, Legros J J, Luyckx A
J Endocrinol Invest. 1985 Aug;8(4):369-72. doi: 10.1007/BF03348516.
Adipsic hypernatremia, a rare disorder, usually secondary to a hypothalamic lesion, is caused by the combination of partial central diabetes insipidus with hypo- or adipsia. We studied a patient who presented with a global hypothalamic dysfunction including adipsic hypernatremia. An extensive work-up disclosed the presence of pseudotumor cerebri and an empty sella turcica. Although endocrine abnormalities including true diabetes insipidus have been reported in conjunction with pseudotumor cerebri or an empty sella, no patient described presented such a global hypothalamic dysfunction or adipsic hypernatremia. The increased intracranial pressure is postulated to be the responsible mechanism for both the empty sella and the hypothalamic dysfunction.
无渴感高钠血症是一种罕见疾病，通常继发于下丘脑病变，由部分中枢性尿崩症合并低渴感或无渴感所致。我们研究了一名出现包括无渴感高钠血症在内的全下丘脑功能障碍的患者。全面检查发现存在假性脑瘤和空蝶鞍。尽管已有报道称假性脑瘤或空蝶鞍会伴有包括真性尿崩症在内的内分泌异常，但此前描述的患者均未出现如此全面的下丘脑功能障碍或无渴感高钠血症。颅内压升高被认为是空蝶鞍和下丘脑功能障碍的致病机制。
