Dubuc P U
Sansum Medical Research Foundation, Santa Barbara, CA 93105, USA.
Growth Dev Aging. 1996 Autumn-Winter;60(3-4):145-51.
Growth, glucose levels and body composition of male and female C57BL/6 ob/ob and lean (?/+) mice were examined between 17 days and 1 year of age. Obese mice displayed three distinct periods of growth with each phase characterized by a different pattern of glucoregulation. Until 4 weeks of age, ob/ob mice had slightly higher rates of weight gain and fat accretion than littermate lean mice. Glycemia was in the normal range and insulin levels were elevated. Shortly after the transition to solid food, ob/ob mice displayed several weeks of increased body growth and very high rates of fat deposition. During this period of rapid weight gain, hyperglycemia arose despite progressively increasing IRI concentrations. Examination of individual obese mice at this time revealed that glycemia was highly correlated with the rate of body fat deposition. The final phase of the ob/ob syndrome began at 3 months of age, as rates of fat deposition abruptly slowed to values slightly less than those of lean mice and glucose values declined to normal although hyperinsulinemia and glucose intolerance persisted. The present results show that ob/ob mice, although characterized throughout life by many metabolic and growth disturbances, only display diabetes mellitus and exaggerated fat deposition during a 6 to 8 week period just after weaning.
对雄性和雌性C57BL/6 ob/ob肥胖小鼠和瘦型（+/+）小鼠在17日龄至1岁龄期间的生长、血糖水平和身体组成进行了检测。肥胖小鼠呈现出三个不同的生长阶段，每个阶段的特征是不同的葡萄糖调节模式。在4周龄之前，ob/ob小鼠的体重增加率和脂肪堆积率略高于同窝瘦型小鼠。血糖处于正常范围，胰岛素水平升高。在过渡到固体食物后不久，ob/ob小鼠出现了几周的身体生长加速和极高的脂肪沉积率。在这个快速体重增加的时期，尽管IRI浓度逐渐升高，但仍出现了高血糖。此时对个体肥胖小鼠的检查显示，血糖与体脂沉积率高度相关。ob/ob综合征的最后阶段始于3月龄，此时脂肪沉积率突然减缓至略低于瘦型小鼠的水平，血糖值降至正常，尽管高胰岛素血症和葡萄糖不耐受仍然存在。目前的结果表明，ob/ob小鼠虽然终生都有许多代谢和生长紊乱的特征，但仅在断奶后6至8周的时间段内表现出糖尿病和过度的脂肪沉积。
