关于豚鼠右心室心肌中介导正性变力作用的β2 - 肾上腺素能受体不存在的功能证据。
Functional evidence against the existence of beta 2-adrenoceptors mediating positive intropic effects in guinea-pig right ventricular myocardium.
作者信息
Mügge A, Oldenburg J, Schmitz W, Scholz H
机构信息
Division of Cardiology, Hannover Medical School, Germany.
出版信息
Naunyn Schmiedebergs Arch Pharmacol. 1997 Jan;355(1):74-8. doi: 10.1007/pl00004920.
In guinea-pig isolated papillary muscles we studied the positive inotropic effects of the beta-adrenoceptor agonists isoprenaline, fenoterol and noradrenaline in the presence and absence of the beta 1-selective antagonist atenolol and the beta 2-adrenoceptor antagonist ICI 118.551. In Schild regression analysis pA2 values, for either atenolol (7.14-7.16) and ICI 118.551 (6.79-6.84) were independent of the agonists used. These results support the view that the inotropic response in guinea-pig ventricular myocardium is mediated by beta 1-adrenoceptors only.
在豚鼠离体乳头肌实验中，我们研究了β肾上腺素能受体激动剂异丙肾上腺素、非诺特罗和去甲肾上腺素在存在和不存在β1选择性拮抗剂阿替洛尔以及β2肾上腺素能受体拮抗剂ICI 118.551的情况下的正性肌力作用。在希尔德回归分析中，阿替洛尔（7.14 - 7.16）和ICI 118.551（6.79 - 6.84）的pA2值与所使用的激动剂无关。这些结果支持这样一种观点，即豚鼠心室心肌中的正性肌力反应仅由β1肾上腺素能受体介导。
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