Blumenthal H T
Department of Psychology, Washington University, USA.
J Gerontol A Biol Sci Med Sci. 1997 Jan;52(1):B1-9. doi: 10.1093/gerona/52a.1.b1.
The greater longevity of humans over other mammalian species is provided, in large part, by the complex neural circuitry of the brain. Assurance of the integrity of this circuitry is partly provided by its neural plasticity. The brain is also protected from adverse systemic phenomena by the blood-brain and blood-cerebrospinal fluid barriers. However, these barriers do not protect the brain from adverse phenomena that originate within the central nervous system. The brain and immune systems share many analogous characteristics; and an immunogenic compartment of the brain is described here that also has the capacity to assure the integrity of its neural circuits and its autonomy. Finally, the role of this compartment in aging and in aging-dependent diseases is discussed.
人类比其他哺乳动物物种寿命更长，这在很大程度上是由大脑复杂的神经回路所决定的。这种神经回路的完整性部分得益于其神经可塑性。血脑屏障和血脑脊液屏障还能保护大脑免受不良全身现象的影响。然而，这些屏障并不能保护大脑免受源自中枢神经系统的不良现象的影响。大脑和免疫系统有许多相似的特征；本文描述了大脑的一个免疫原性区域，它也有能力确保其神经回路的完整性及其自主性。最后，讨论了这个区域在衰老和衰老相关疾病中的作用。
