Aguirre M A, Jones C N, Pei D, Villa M L, Reaven G M
Department of Medicine, Stanford University School of Medicine, USA.
J Gerontol A Biol Sci Med Sci. 1997 Jan;52(1):M56-60. doi: 10.1093/gerona/52a.1.m56.
This study was initiated to test the hypothesis that older, healthy, nondiabetic Mexican American women would be relatively resistant to insulin-mediated glucose disposal, hyperinsulinemic, and dyslipidemic as compared to a matched group of non-Hispanic White (NHW) women.
The study, cross-sectional in nature, involved 14 Mexican American and 19 NHW healthy, normotensive nondiabetic, postmenopausal women of similar age and body mass index. It took place in the General Clinical Research Center at Stanford Medical Center. Measurements were made of fasting plasma glucose, insulin and lipid concentrations, and plasma glucose and insulin concentrations following a 75 gram oral glucose challenge. Resistance to insulin-mediated glucose disposal was estimated by the steady-state plasma glucose (SSPG) concentration achieved at the end of a 3-hour constant infusion of glucose, insulin, and somatostatin.
Mexican American women had significantly greater glucose (p < .001) and insulin (p < .001) responses to the oral glucose challenge than did the NHW women. Resistance to insulin-mediated glucose disposal was increased in Mexican American women (SSPG 195 +/- 25 mg/dl compared to 137 +/- 18 mg/dl in NHW; p < .001). While total cholesterol, low density lipoprotein (LDL)-cholesterol, and triglyceride concentrations were not significantly different in the two ethnic groups, high density lipoprotein (HDL)-cholesterol was significantly lower in the Mexican American women (51 mg/dl vs 61 mg/dl; p = .04).
Older Mexican American women are more insulin resistant, glucose intolerant, and hyperinsulinemic, and have a lower HDL-cholesterol than a matched group of non-Hispanic White peers. These results were observed despite the exclusion of individuals with non-insulin dependent diabetes mellitus (NIDDM).
本研究旨在验证以下假设：与年龄匹配的非西班牙裔白人（NHW）女性相比，年龄较大、健康且非糖尿病的墨西哥裔美国女性对胰岛素介导的葡萄糖处置、高胰岛素血症和血脂异常具有相对抗性。
该研究本质上为横断面研究，纳入了14名墨西哥裔美国女性和19名NHW健康、血压正常且非糖尿病的绝经后女性，她们年龄和体重指数相似。研究在斯坦福医疗中心的综合临床研究中心进行。测量了空腹血浆葡萄糖、胰岛素和脂质浓度，以及75克口服葡萄糖耐量试验后的血浆葡萄糖和胰岛素浓度。通过在3小时持续输注葡萄糖、胰岛素和生长抑素结束时达到的稳态血浆葡萄糖（SSPG）浓度来估计对胰岛素介导的葡萄糖处置的抗性。
与NHW女性相比，墨西哥裔美国女性对口服葡萄糖耐量试验的葡萄糖（p <.001）和胰岛素（p <.001）反应明显更大。墨西哥裔美国女性对胰岛素介导的葡萄糖处置的抗性增加（SSPG为195 +/- 25 mg/dl，而NHW为137 +/- 18 mg/dl；p <.001）。虽然两个种族群体的总胆固醇、低密度脂蛋白（LDL）胆固醇和甘油三酯浓度没有显著差异，但墨西哥裔美国女性的高密度脂蛋白（HDL）胆固醇显著较低（51 mg/dl对61 mg/dl；p =.04）。
与年龄匹配的非西班牙裔白人同龄人相比，年龄较大的墨西哥裔美国女性胰岛素抵抗更强、葡萄糖不耐受且高胰岛素血症，并且HDL胆固醇更低。尽管排除了非胰岛素依赖型糖尿病（NIDDM）患者，但仍观察到了这些结果。
