甲状腺功能亢进对猫肾功能影响的研究。
Investigation of the effects of hyperthyroidism on renal function in the cat.
作者信息
Adams W H, Daniel G B, Legendre A M
机构信息
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville 37901-1071 USA.
出版信息
Can J Vet Res. 1997 Jan;61(1):53-6.
Abstract
This study evaluated the effects of thyroxine on renal function in the cat. Baseline serum thyroxine (T4) concentrations, clinicopathologic data (complete blood count [CBC], serum chemistry panel, urinalysis), and nuclear medicine determinations of glomerular filtration rate (GFR), effective renal plasma flow (ERPF), and effective renal blood flow (ERBF) were measured in 10 normal adult cats. Cats were then injected with thyroxine (T4) (50 micrograms/kg SQ) daily for 30 d to induce hyperthyroidism. Clinicopathologic and nuclear medicine studies were repeated at 30 d. Cats injected with thyroxine had significant increases in T4, GFR, and ERBF and significant declines in serum creatinine and blood urea nitrogen (BUN) values. Administration of high doses of exogenous thyroxine to cats results in significant stimulation of renal function.
摘要
本研究评估了甲状腺素对猫肾功能的影响。对10只正常成年猫测量了基线血清甲状腺素（T4）浓度、临床病理数据（全血细胞计数[CBC]、血清化学指标、尿液分析）以及肾小球滤过率（GFR）、有效肾血浆流量（ERPF）和有效肾血流量（ERBF）的核医学测定值。然后，每天给猫皮下注射甲状腺素（T4）（50微克/千克），持续30天以诱导甲状腺功能亢进。在30天时重复进行临床病理和核医学研究。注射甲状腺素的猫的T4、GFR和ERBF显著升高，血清肌酐和血尿素氮（BUN）值显著下降。给猫施用高剂量外源性甲状腺素会显著刺激肾功能。
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