Rath P M, Oeffelke R, Müller K D, Ansorg R
Institut für Medizinische Mikrobiologie, Universität-GH Essen, Germany.
Mycoses. 1996 Sep-Oct;39(9-10):367-70. doi: 10.1111/j.1439-0507.1996.tb00155.x.
A commercially available antigen assay (Pastorex Aspergillus) was used to detect Aspergillus antigen in serial bronchoalveolar lavage (BAL) fluids and sera of patients undergoing bone marrow transplantation (six patients with autopsyproven aspergillosis and 10 control patients without evidence of fungal infection). Aspergillus antigen was not detected in 17 BAL fluids of the six patients with proven aspergillosis. In two of the six patients the assay gave positive results in serum specimens. Three of the 10 control patients showed reactive BAL fluids. It is concluded that the latex agglutination assay of BAL fluids has no value in the diagnosis of invasive (pulmonary) aspergillosis in patients undergoing bone marrow transplantation.
采用一种市售的抗原检测法（Pastorex曲霉菌检测法）检测接受骨髓移植患者的系列支气管肺泡灌洗（BAL）液和血清中的曲霉菌抗原（6例经尸检证实患有曲霉菌病的患者和10例无真菌感染证据的对照患者）。6例经证实患有曲霉菌病的患者的17份BAL液中未检测到曲霉菌抗原。6例患者中有2例的血清标本检测结果为阳性。10例对照患者中有3例的BAL液呈反应性。结论是，BAL液的乳胶凝集试验对诊断接受骨髓移植患者的侵袭性（肺部）曲霉菌病无价值。
