• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Discovery of the hemochromatosis gene will require rethinking the regulation of iron metabolism.

作者信息

Fleet J C

机构信息

Jean Mayer Human Nutrition Research Center on Aging, Tufts University, Boston MA 02111, USA.

出版信息

Nutr Rev. 1996 Sep;54(9):285-7. doi: 10.1111/j.1753-4887.1996.tb03949.x.

DOI:10.1111/j.1753-4887.1996.tb03949.x
PMID:9009670
Abstract

The identity of the protein responsible for hemochromatosis, the iron overload disease, has eluded scientists for years. However, a recent report identifies the gene where the hemochromatosis defect lies. It is a gene that encodes a major histocompatibility complex (MHC) class-1-like protein called HLA-H. The mechanism by which an HLA-H defect alters iron metabolism is still unidentified. However, this new discovery will certainly ignite a new wave of study into the physiology of iron metabolism and its regulation.

摘要

相似文献

1
Discovery of the hemochromatosis gene will require rethinking the regulation of iron metabolism.
Nutr Rev. 1996 Sep;54(9):285-7. doi: 10.1111/j.1753-4887.1996.tb03949.x.
2
The haemochromatosis gene.血色素沉着症基因
J Hepatol. 1997 Apr;26(4):941-4. doi: 10.1016/s0168-8278(97)80265-6.
3
Hemochromatosis: a genetic defect in iron metabolism.血色素沉着症：铁代谢的一种基因缺陷。
Bioessays. 1998 Jul;20(7):562-8. doi: 10.1002/(SICI)1521-1878(199807)20:7<562::AID-BIES7>3.0.CO;2-M.
4
Hemochromatosis and iron needs.血色素沉着症与铁需求
Nutr Rev. 1998 Feb;56(2 Pt 2):s30-7; discussion s54-75. doi: 10.1111/j.1753-4887.1998.tb01684.x.
5
[The molecular genetics of hematochromatosis].
Gastroenterol Clin Biol. 2002 Jun-Jul;26(6-7):563-9.
6
The "anemic" enterocyte in hereditary hemochromatosis: molecular insights into the control of intestinal iron absorption.遗传性血色素沉着症中的“贫血”肠上皮细胞：肠道铁吸收控制的分子见解
Nutr Rev. 2002 May;60(5 Pt 1):144-8. doi: 10.1301/00296640260093814.
7
Hereditary hemochromatosis: recent advances in molecular genetics and clinical management.遗传性血色素沉着症：分子遗传学与临床管理的最新进展
Haematologica. 1997 Jan-Feb;82(1):77-84.
8
The structure and function of HFE.遗传性血色素沉着症蛋白（HFE）的结构与功能
Bioessays. 2000 Jul;22(7):595-8. doi: 10.1002/1521-1878(200007)22:7<595::AID-BIES1>3.0.CO;2-E.
9
[Hereditary hemochromatosis].[遗传性血色素沉着症]
Rev Gastroenterol Peru. 2001 Jan-Mar;21(1):42-55.
10
Iron, HFE, and hemochromatosis update.
J Investig Med. 1997 Dec;45(9):518-29.