Wolf G
Department of Nutritional Sciences, University of California, Berkeley 94720-3104, USA.
Nutr Rev. 1996 Sep;54(9):290-2. doi: 10.1111/j.1753-4887.1996.tb03951.x.
Adipocyte differentiation and the homeostasis of fat cell number are regulated by a nuclear receptor protein, the peroxisome proliferator-activated receptor (PPAR gamma). The endogenous ligand is thought to be 15-deoxy-delta 12,14-prostaglandin J2-Thiazolidinedione, an antidiabetic drug, closely mimics the action of the prostaglandin, suggesting a regulatory role by the prostaglandin and PPAR gamma both in adipocyte differentiation and in glucose homeostasis.
脂肪细胞分化和脂肪细胞数量的稳态由一种核受体蛋白——过氧化物酶体增殖物激活受体（PPARγ）调控。内源性配体被认为是15-脱氧-δ12,14-前列腺素J2。噻唑烷二酮类抗糖尿病药物与前列腺素的作用极为相似，这表明前列腺素和PPARγ在脂肪细胞分化及葡萄糖稳态中均发挥调节作用。
