Activation, cellular redistribution and enhanced degradation of the G proteins Gq and G11 by endogenously expressed and transfected phospholipase C-coupled muscarinic m1 acetylcholine receptors.
作者信息
Mullaney I, Caulfield M P, Svoboda P, Milligan G
机构信息
Division of Biochemistry and Molecular Biology, University of Glasgow, UK.
出版信息
Prog Brain Res. 1996;109:181-7. doi: 10.1016/s0079-6123(08)62100-7.
PMID:9009705
Abstract
摘要
相似文献
1
Activation, cellular redistribution and enhanced degradation of the G proteins Gq and G11 by endogenously expressed and transfected phospholipase C-coupled muscarinic m1 acetylcholine receptors.内源性表达和转染的磷脂酶C偶联毒蕈碱型m1乙酰胆碱受体对G蛋白Gq和G11的激活、细胞内重新分布及增强降解作用
Prog Brain Res. 1996;109:181-7. doi: 10.1016/s0079-6123(08)62100-7.
2
3
Agonist-induced transfer of the alpha subunits of the guanine-nucleotide-binding regulatory proteins Gq and G11 and of muscarinic m1 acetylcholine receptors from plasma membranes to a light-vesicular membrane fraction.激动剂诱导鸟嘌呤核苷酸结合调节蛋白Gq和G11的α亚基以及毒蕈碱型m1乙酰胆碱受体从质膜转移至轻小泡膜组分。
Eur J Biochem. 1994 Sep 1;224(2):455-62. doi: 10.1111/j.1432-1033.1994.00455.x.
4
The human muscarinic M1 acetylcholine receptor, when express in CHO cells, activates and downregulates both Gq alpha and G11 alpha equally and non-selectively.人毒蕈碱型M1乙酰胆碱受体在CHO细胞中表达时，会同等且非选择性地激活和下调Gqα和G11α。
FEBS Lett. 1993 Jun 14;324(2):241-5. doi: 10.1016/0014-5793(93)81401-k.
5
Characterization of Gq family G proteins GL1 alpha (G14 alpha), GL2 alpha (G11 alpha), and Gq alpha expressed in the baculovirus-insect cell system.杆状病毒-昆虫细胞系统中表达的Gq家族G蛋白GL1α（G14α）、GL2α（G11α）和Gqα的特性分析
J Biol Chem. 1995 Mar 17;270(11):6246-53. doi: 10.1074/jbc.270.11.6246.
6
Agonist activation of transfected human M1 muscarinic acetylcholine receptors in CHO cells results in down-regulation of both the receptor and the alpha subunit of the G-protein Gq.在CHO细胞中，转染的人M1毒蕈碱型乙酰胆碱受体的激动剂激活导致该受体和G蛋白Gq的α亚基均下调。
Biochem J. 1993 Jan 1;289 ( Pt 1)(Pt 1):125-31. doi: 10.1042/bj2890125.
7
Enhanced degradation of the phosphoinositidase C-linked guanine-nucleotide-binding protein Gq alpha/G11 alpha following activation of the human M1 muscarinic acetylcholine receptor expressed in CHO cells.在CHO细胞中表达的人M1毒蕈碱型乙酰胆碱受体激活后，磷酸肌醇酶C连接的鸟嘌呤核苷酸结合蛋白Gqα/G11α的降解增强。
Biochem J. 1993 Jul 15;293 ( Pt 2)(Pt 2):495-9. doi: 10.1042/bj2930495.
8
Participation of small GTP-binding proteins in m3 muscarinic acetylcholine receptor signalling to phospholipase D and C.小GTP结合蛋白参与M3型毒蕈碱型乙酰胆碱受体向磷脂酶D和C的信号传导。
Prog Brain Res. 1996;109:209-16. doi: 10.1016/s0079-6123(08)62104-4.
9
Transfected muscarinic acetylcholine receptors selectively couple to Gi-type G proteins and Gq/11.转染的毒蕈碱型乙酰胆碱受体选择性地与Gi型G蛋白和Gq/11偶联。
Mol Pharmacol. 1994 May;45(5):890-8.
10
Residues specifically involved in down-regulation but not internalization of the m1 muscarinic acetylcholine receptor.特异性参与M1毒蕈碱型乙酰胆碱受体内化调控但不参与内化过程的残基。
J Neurochem. 1997 Feb;68(2):601-9. doi: 10.1046/j.1471-4159.1997.68020601.x.
Zotero 插件