Arnold W H, Sperber G H, Machin G A
Department of Anatomy II, Faculty of Dentistry, University of Witten/Herdecke, Germany.
Ann Anat. 1996 Dec;178(6):553-8. doi: 10.1016/S0940-9602(96)80117-8.
In three human fetuses with synophthalmic holoprosencephaly (8, 14, 23 weeks post conceptionem) the circle of Willis was studied using serial histological sections and computer aided three dimensional reconstruction methods. This structure was abnormal in all cases. In two cases the anterior communicating arteries were absent. In all cases the anterior cerebral arteries could not be found. One case showed an incomplete circle with no posterior communicating artery. The results indicate that the malformation of the circle of Willis reflects the malformation of the brain.
在3例患独眼全前脑畸形的人类胎儿（受孕后8、14、23周）中，采用连续组织学切片和计算机辅助三维重建方法对Willis环进行了研究。在所有病例中，该结构均异常。2例病例中，前交通动脉缺如。在所有病例中，均未发现大脑前动脉。1例病例显示Willis环不完整，无后交通动脉。结果表明，Willis环畸形反映了脑部畸形。
