Klepser M E, Klepser T B
Division of Clinical and Administrative Pharmacy, College of Pharmacy, University of Iowa, Iowa City 52242-1112, USA.
Drugs. 1997 Jan;53(1):40-73. doi: 10.2165/00003495-199753010-00004.
The AIDS epidemic has led to the emergence of several disease entities which in the pre-AIDS era were rare or seemingly innocuous. Experience of treating these diseases varies. In some instances, such as Pneumocystis carinii pneumonia, there is an abundance of published literature to direct our course of action. However, for many of these newly recognised diseases our treatment experience is limited. Furthermore, in many instances, well controlled trials evaluating treatment modalities in the AIDS population are lacking. We have identified 13 disease entities (P. carinii pneumonia, toxoplasmosis, cryptococcosis, histoplasmosis, Mycobacterium tuberculosis, Mycobacterium avium complex, cytomegalovirus, coccidioidomycosis, isosporiasis, candidosis, Kaposi's sarcoma, herpes simplex virus, and varicella zoster virus) and have reviewed the current literature with regard to their treatment.
艾滋病流行导致了几种疾病实体的出现，这些疾病在艾滋病出现之前的时代较为罕见或看似无害。治疗这些疾病的经验各不相同。在某些情况下，如卡氏肺孢子虫肺炎，有大量已发表的文献指导我们的治疗行动。然而，对于许多这些新认识的疾病，我们的治疗经验有限。此外，在许多情况下，缺乏评估艾滋病患者治疗方式的严格对照试验。我们确定了13种疾病实体（卡氏肺孢子虫肺炎、弓形虫病、隐球菌病、组织胞浆菌病、结核分枝杆菌、鸟分枝杆菌复合体、巨细胞病毒、球孢子菌病、等孢球虫病、念珠菌病、卡波西肉瘤、单纯疱疹病毒和水痘带状疱疹病毒），并回顾了关于其治疗的当前文献。
