Hester R K, Carrier O
Arch Int Pharmacodyn Ther. 1977 May;227(1):4-10.
In order to determine whether or not reserpine-induced supersensitivity was affected or reflected in differences in sensitivities to acetylcholine and isoproterenol in different segments of the rabbit aorta, segments of aorta, taken at two different distances from the arch, were tested for their sensitivities to these two agonists. Sensitivity and maximum responses to acetylcholine were lower in the more distal segment. Sensitivity to isoproterenol of the segments was not different while the maximum responses were lower in the more distal segment. Reserpine-induced supersensitivity to both agonists was similar in both aortic segments.
为了确定利血平诱导的超敏反应是否受到影响或反映在兔主动脉不同节段对乙酰胆碱和异丙肾上腺素敏感性的差异上，从距主动脉弓两个不同距离处获取的主动脉节段，检测其对这两种激动剂的敏感性。在更远端的节段中，对乙酰胆碱的敏感性和最大反应较低。各节段对异丙肾上腺素的敏感性无差异，而在更远端的节段中最大反应较低。两个主动脉节段中利血平诱导的对两种激动剂的超敏反应相似。
