Tam D A
Division of Child Neurology, Medical College of Virginia, Virginia Commonwealth University, Richmond, USA.
J Child Neurol. 1997 Jan;12(1):19-21. doi: 10.1177/088307389701200103.
Stroke is a significant complication of sickle cell anemia in the pediatric population. The pathophysiology of stroke in sickle cell anemia remains unclear. Protein C and protein S activities were measured in children with sickle cell anemia and stroke, and compared to those with sickle cell anemia who were neurologically normal. Results showed significantly decreased levels of both protein C and protein S activities in children with sickle cell anemia who have had a stroke. This pilot study suggests that a possible coagulopathic state in children with sickle cell anemia may be associated with an increased risk for cerebrovascular disease. Further research in this area is indicated.
中风是小儿镰状细胞贫血的一种重要并发症。镰状细胞贫血中风的病理生理学仍不清楚。对患有镰状细胞贫血和中风的儿童进行了蛋白C和蛋白S活性的测量，并与神经功能正常的镰状细胞贫血儿童进行了比较。结果显示，患有中风的镰状细胞贫血儿童的蛋白C和蛋白S活性水平均显著降低。这项初步研究表明，镰状细胞贫血儿童可能存在的凝血异常状态可能与脑血管疾病风险增加有关。这一领域需要进一步研究。
